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Glycation of Lys-16 and Arg-5 in amyloid-β and the presence of Cu2+ play a major role in the oxidative stress mechanism of Alzheimer's disease.
Fica-Contreras SM, Shuster SO, Durfee ND, Bowe GJK, Henning NJ, Hill SA, Vrla GD, Stillman DR, Suralik KM, Sandwick RK, Choi S. Fica-Contreras SM, et al. Among authors: henning nj. J Biol Inorg Chem. 2017 Dec;22(8):1211-1222. doi: 10.1007/s00775-017-1497-5. Epub 2017 Oct 16. J Biol Inorg Chem. 2017. PMID: 29038915
Structure and Characterization of a Covalent Inhibitor of Src Kinase.
Gurbani D, Du G, Henning NJ, Rao S, Bera AK, Zhang T, Gray NS, Westover KD. Gurbani D, et al. Among authors: henning nj. Front Mol Biosci. 2020 May 19;7:81. doi: 10.3389/fmolb.2020.00081. eCollection 2020. Front Mol Biosci. 2020. PMID: 32509799 Free PMC article.
Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2.
Du G, Jiang J, Wu Q, Henning NJ, Donovan KA, Yue H, Che J, Lu W, Fischer ES, Bardeesy N, Zhang T, Gray NS. Du G, et al. Among authors: henning nj. Angew Chem Int Ed Engl. 2021 Jul 12;60(29):15905-15911. doi: 10.1002/anie.202101328. Epub 2021 Jun 14. Angew Chem Int Ed Engl. 2021. PMID: 33915015 Free PMC article.
Exploring the target scope of KEAP1 E3 ligase-based PROTACs.
Du G, Jiang J, Henning NJ, Safaee N, Koide E, Nowak RP, Donovan KA, Yoon H, You I, Yue H, Eleuteri NA, He Z, Li Z, Huang HT, Che J, Nabet B, Zhang T, Fischer ES, Gray NS. Du G, et al. Among authors: henning nj. Cell Chem Biol. 2022 Oct 20;29(10):1470-1481.e31. doi: 10.1016/j.chembiol.2022.08.003. Epub 2022 Sep 6. Cell Chem Biol. 2022. PMID: 36070758 Free PMC article.
Deubiquitinase-targeting chimeras for targeted protein stabilization.
Henning NJ, Boike L, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse MJ, Dovala D, McGregor LM, Valdez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Henning NJ, et al. Nat Chem Biol. 2022 Apr;18(4):412-421. doi: 10.1038/s41589-022-00971-2. Epub 2022 Feb 24. Nat Chem Biol. 2022. PMID: 35210618 Free PMC article.
Advances in covalent drug discovery.
Boike L, Henning NJ, Nomura DK. Boike L, et al. Among authors: henning nj. Nat Rev Drug Discov. 2022 Dec;21(12):881-898. doi: 10.1038/s41573-022-00542-z. Epub 2022 Aug 25. Nat Rev Drug Discov. 2022. PMID: 36008483 Free PMC article. Review.
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