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Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma.
Xiao L, Somers K, Murray J, Pandher R, Karsa M, Ronca E, Bongers A, Terry R, Ehteda A, Gamble LD, Issaeva N, Leonova KI, O'Connor A, Mayoh C, Venkat P, Quek H, Brand J, Kusuma FK, Pettitt JA, Mosmann E, Kearns A, Eden G, Alfred S, Allan S, Zhai L, Kamili A, Gifford AJ, Carter DR, Henderson MJ, Fletcher JI, Marshall G, Johnstone RW, Cesare AJ, Ziegler DS, Gudkov AV, Gurova KV, Norris MD, Haber M. Xiao L, et al. Among authors: henderson mj. Clin Cancer Res. 2021 Aug 1;27(15):4338-4352. doi: 10.1158/1078-0432.CCR-20-2357. Epub 2021 May 16. Clin Cancer Res. 2021. PMID: 33994371 Free PMC article.
Mechanism of relapse in pediatric acute lymphoblastic leukemia.
Henderson MJ, Choi S, Beesley AH, Sutton R, Venn NC, Marshall GM, Kees UR, Haber M, Norris MD. Henderson MJ, et al. Cell Cycle. 2008 May 15;7(10):1315-20. doi: 10.4161/cc.7.10.5885. Epub 2008 Feb 29. Cell Cycle. 2008. PMID: 18418081
ABC transporters in cancer: more than just drug efflux pumps.
Fletcher JI, Haber M, Henderson MJ, Norris MD. Fletcher JI, et al. Among authors: henderson mj. Nat Rev Cancer. 2010 Feb;10(2):147-56. doi: 10.1038/nrc2789. Epub 2010 Jan 15. Nat Rev Cancer. 2010. PMID: 20075923
Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells.
Porro A, Haber M, Diolaiti D, Iraci N, Henderson M, Gherardi S, Valli E, Munoz MA, Xue C, Flemming C, Schwab M, Wong JH, Marshall GM, Della Valle G, Norris MD, Perini G. Porro A, et al. J Biol Chem. 2010 Jun 18;285(25):19532-43. doi: 10.1074/jbc.M109.078584. Epub 2010 Mar 16. J Biol Chem. 2010. PMID: 20233711 Free PMC article.
ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.
Henderson MJ, Haber M, Porro A, Munoz MA, Iraci N, Xue C, Murray J, Flemming CL, Smith J, Fletcher JI, Gherardi S, Kwek CK, Russell AJ, Valli E, London WB, Buxton AB, Ashton LJ, Sartorelli AC, Cohn SL, Schwab M, Marshall GM, Perini G, Norris MD. Henderson MJ, et al. J Natl Cancer Inst. 2011 Aug 17;103(16):1236-51. doi: 10.1093/jnci/djr256. Epub 2011 Jul 28. J Natl Cancer Inst. 2011. PMID: 21799180 Free PMC article.
High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).
Cheung L, Flemming CL, Watt F, Masada N, Yu DM, Huynh T, Conseil G, Tivnan A, Polinsky A, Gudkov AV, Munoz MA, Vishvanath A, Cooper DM, Henderson MJ, Cole SP, Fletcher JI, Haber M, Norris MD. Cheung L, et al. Among authors: henderson mj. Biochem Pharmacol. 2014 Sep 1;91(1):97-108. doi: 10.1016/j.bcp.2014.05.023. Epub 2014 Jun 25. Biochem Pharmacol. 2014. PMID: 24973542
Effective targeting of the P53-MDM2 axis in preclinical models of infant MLL-rearranged acute lymphoblastic leukemia.
Richmond J, Carol H, Evans K, High L, Mendomo A, Robbins A, Meyer C, Venn NC, Marschalek R, Henderson M, Sutton R, Kurmasheva RT, Kees UR, Houghton PJ, Smith MA, Lock RB. Richmond J, et al. Clin Cancer Res. 2015 Mar 15;21(6):1395-405. doi: 10.1158/1078-0432.CCR-14-2300. Epub 2015 Jan 8. Clin Cancer Res. 2015. PMID: 25573381 Free PMC article.
243 results