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Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease.
Williams D, Glasstetter LM, Jong TT, Kapoor A, Zhu S, Zhu Y, Gehrlein A, Vocadlo DJ, Jagasia R, Marugan JJ, Sidransky E, Henderson MJ, Chen Y. Williams D, et al. Among authors: henderson mj. bioRxiv [Preprint]. 2024 Mar 27:2024.03.22.586364. doi: 10.1101/2024.03.22.586364. bioRxiv. 2024. PMID: 38712038 Free PMC article. Preprint.
Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice.
Chandía-Cristi A, Gutiérrez DA, Dulcey AE, Lara M, Vargas L, Lin YH, Jimenez-Muñoz P, Larenas G, Xu X, Wang A, Owens A, Dextras C, Chen Y, Pinto C, Marín T, Almarza-Salazar H, Acevedo K, Cancino GI, Hu X, Rojas P, Ferrer M, Southall N, Henderson MJ, Zanlungo S, Marugan JJ, Álvarez R A. Chandía-Cristi A, et al. Among authors: henderson mj. Cell Rep. 2024 Apr 23;43(5):114144. doi: 10.1016/j.celrep.2024.114144. Online ahead of print. Cell Rep. 2024. PMID: 38656874 Free article.
Overcoming brain-derived therapeutic resistance in HER2+ breast cancer brain metastasis.
Ippolitov D, Lin YH, Spence J, Glogowska A, Thanasupawat T, Beiko J, Del Bigio MR, Xu X, Wang A, Calvo R, Kapoor A, Marugan JJ, Henderson MJ, Klonisch T, Hombach-Klonisch S. Ippolitov D, et al. Among authors: henderson mj. bioRxiv [Preprint]. 2024 Feb 22:2024.02.19.581073. doi: 10.1101/2024.02.19.581073. bioRxiv. 2024. PMID: 38529509 Free PMC article. Preprint.
FDA-approved disulfiram as a novel treatment for aggressive leukemia.
Karsa M, Xiao L, Ronca E, Bongers A, Spurling D, Karsa A, Cantilena S, Mariana A, Failes TW, Arndt GM, Cheung LC, Kotecha RS, Sutton R, Lock RB, Williams O, de Boer J, Haber M, Norris MD, Henderson MJ, Somers K. Karsa M, et al. Among authors: henderson mj. J Mol Med (Berl). 2024 Apr;102(4):507-519. doi: 10.1007/s00109-023-02414-4. Epub 2024 Feb 13. J Mol Med (Berl). 2024. PMID: 38349407 Free PMC article.
Phenotype plasticity and altered sensitivity to chemotherapeutic agents in aggressive prostate cancer cells.
Paxson AI, Chang LH, Gard JMC, Harryman WL, Nelson CS, Salmon SB, Marr KD, Wachsmuth LM, Ramanathan A, Ran J, Kapoor A, Marugan JJ, Henderson MJ, Sanchez TW, Cress AE. Paxson AI, et al. Among authors: henderson mj. Front Cell Dev Biol. 2023 Nov 16;11:1285372. doi: 10.3389/fcell.2023.1285372. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 38046670 Free PMC article.
Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes.
Yan W, Zhong Y, Hu X, Xu T, Zhang Y, Kales S, Qu Y, Talley DC, Baljinnyam B, LeClair CA, Simeonov A, Polster BM, Huang R, Ye Y, Rai G, Henderson MJ, Tao D, Fang S. Yan W, et al. Among authors: henderson mj. Nat Commun. 2023 Aug 9;14(1):4798. doi: 10.1038/s41467-023-40537-x. Nat Commun. 2023. PMID: 37558718 Free PMC article.
Core Body Temperatures in Intermittent Sports: A Systematic Review.
Henderson MJ, Grandou C, Chrismas BCR, Coutts AJ, Impellizzeri FM, Taylor L. Henderson MJ, et al. Sports Med. 2023 Nov;53(11):2147-2170. doi: 10.1007/s40279-023-01892-3. Epub 2023 Aug 1. Sports Med. 2023. PMID: 37526813 Free PMC article.
243 results