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Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism.
Magnotti F, Chirita D, Dalmon S, Martin A, Bronnec P, Sousa J, Helynck O, Lee W, Kastner DL, Chae JJ, McDermott MF, Belot A, Popoff M, Sève P, Georgin-Lavialle S, Munier-Lehmann H, Tran TA, De Langhe E, Wouters C, Jamilloux Y, Henry T. Magnotti F, et al. Among authors: helynck o. Cell Rep. 2022 Oct 11;41(2):111472. doi: 10.1016/j.celrep.2022.111472. Cell Rep. 2022. PMID: 36223753 Free PMC article.
Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT.
Dabo S, Maillard P, Collados Rodriguez M, Hansen MD, Mazouz S, Bigot DJ, Tible M, Janvier G, Helynck O, Cassonnet P, Jacob Y, Bellalou J, Gatignol A, Patel RC, Hugon J, Munier-Lehmann H, Meurs EF. Dabo S, et al. Among authors: helynck o. Sci Rep. 2017 Nov 23;7(1):16129. doi: 10.1038/s41598-017-16089-8. Sci Rep. 2017. PMID: 29170442 Free PMC article.
First-in-class allosteric inhibitors of bacterial IMPDHs.
Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H. Alexandre T, et al. Among authors: helynck o. Eur J Med Chem. 2019 Apr 1;167:124-132. doi: 10.1016/j.ejmech.2019.01.064. Epub 2019 Feb 2. Eur J Med Chem. 2019. PMID: 30769241 Free article.
Synergy of the antibiotic colistin with echinocandin antifungals in Candida species.
Zeidler U, Bougnoux ME, Lupan A, Helynck O, Doyen A, Garcia Z, Sertour N, Clavaud C, Munier-Lehmann H, Saveanu C, d'Enfert C. Zeidler U, et al. Among authors: helynck o. J Antimicrob Chemother. 2013 Jun;68(6):1285-96. doi: 10.1093/jac/dks538. Epub 2013 Feb 1. J Antimicrob Chemother. 2013. PMID: 23378416 Free article.
High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.
Aulner N, Danckaert A, Rouault-Hardoin E, Desrivot J, Helynck O, Commere PH, Munier-Lehmann H, Späth GF, Shorte SL, Milon G, Prina E. Aulner N, et al. Among authors: helynck o. PLoS Negl Trop Dis. 2013 Apr 4;7(4):e2154. doi: 10.1371/journal.pntd.0002154. Print 2013. PLoS Negl Trop Dis. 2013. PMID: 23593521 Free PMC article.
21 results