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Cell-specific regulation of gene expression using splicing-dependent frameshifting.
Ling JP, Bygrave AM, Santiago CP, Carmen-Orozco RP, Trinh VT, Yu M, Li Y, Liu Y, Bowden KD, Duncan LH, Han J, Taneja K, Dongmo R, Babola TA, Parker P, Jiang L, Leavey PJ, Smith JJ, Vistein R, Gimmen MY, Dubner B, Helmenstine E, Teodorescu P, Karantanos T, Ghiaur G, Kanold PO, Bergles D, Langmead B, Sun S, Nielsen KJ, Peachey N, Singh MS, Dalton WB, Rajaii F, Huganir RL, Blackshaw S. Ling JP, et al. Among authors: helmenstine e. Nat Commun. 2022 Oct 1;13(1):5773. doi: 10.1038/s41467-022-33523-2. Nat Commun. 2022. PMID: 36182931 Free PMC article.
The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia.
Karantanos T, Teodorescu P, Perkins B, Christodoulou I, Esteb C, Varadhan R, Helmenstine E, Rajkhowa T, Paun BC, Bonifant C, Dalton WB, Gondek LP, Moliterno AR, Levis MJ, Ghiaur G, Jones RJ. Karantanos T, et al. Among authors: helmenstine e. Sci Adv. 2022 Feb 18;8(7):eabl8952. doi: 10.1126/sciadv.abl8952. Epub 2022 Feb 18. Sci Adv. 2022. PMID: 35179961 Free PMC article.
Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation.
Dalton WB, Helmenstine E, Walsh N, Gondek LP, Kelkar DS, Read A, Natrajan R, Christenson ES, Roman B, Das S, Zhao L, Leone RD, Shinn D, Groginski T, Madugundu AK, Patil A, Zabransky DJ, Medford A, Lee J, Cole AJ, Rosen M, Thakar M, Ambinder A, Donaldson J, DeZern AE, Cravero K, Chu D, Madero-Marroquin R, Pandey A, Hurley PJ, Lauring J, Park BH. Dalton WB, et al. Among authors: helmenstine e. J Clin Invest. 2019 Aug 8;129(11):4708-4723. doi: 10.1172/JCI125022. J Clin Invest. 2019. PMID: 31393856 Free PMC article.
The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts.
Choi IY, Ling J, Zhang J, Helmenstine E, Walter W, Bergman R, Philippe C, Manley J, Rouault-Pierre K, Li B, Wiseman D, Ouseph M, Bernard E, Li X, Haferlach T, Fazal S, Jain T, Gocke C, DeZern A, Dalton WB. Choi IY, et al. Among authors: helmenstine e. Res Sq [Preprint]. 2023 Apr 14:rs.3.rs-2802265. doi: 10.21203/rs.3.rs-2802265/v1. Res Sq. 2023. PMID: 37090662 Free PMC article. Preprint.