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Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors.
O'Dowd CR, Helm MD, Rountree JSS, Flasz JT, Arkoudis E, Miel H, Hewitt PR, Jordan L, Barker O, Hughes C, Rozycka E, Cassidy E, McClelland K, Odrzywol E, Page N, Feutren-Burton S, Dvorkin S, Gavory G, Harrison T. O'Dowd CR, et al. Among authors: helm md. ACS Med Chem Lett. 2018 Feb 21;9(3):238-243. doi: 10.1021/acsmedchemlett.7b00512. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541367 Free PMC article.
USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF.
Jurisic A, Sung PJ, Wappett M, Daubriac J, Lobb IT, Kung WW, Crawford N, Page N, Cassidy E, Feutren-Burton S, Rountree JSS, Helm MD, O'Dowd CR, Kennedy RD, Gavory G, Cranston AN, Longley DB, Jacq X, Harrison T. Jurisic A, et al. Among authors: helm md. Clin Transl Med. 2024 Apr;14(4):e1648. doi: 10.1002/ctm2.1648. Clin Transl Med. 2024. PMID: 38602256 Free PMC article.
Total synthesis of (+)-pleuromutilin.
Fazakerley NJ, Helm MD, Procter DJ. Fazakerley NJ, et al. Among authors: helm md. Chemistry. 2013 May 17;19(21):6718-23. doi: 10.1002/chem.201300968. Epub 2013 Apr 15. Chemistry. 2013. PMID: 23589420
Simple inexpensive boron electrophiles for direct arene borylation.
Del Grosso A, Helm MD, Solomon SA, Caras-Quintero D, Ingleson MJ. Del Grosso A, et al. Among authors: helm md. Chem Commun (Camb). 2011 Dec 14;47(46):12459-61. doi: 10.1039/c1cc14226g. Epub 2011 Oct 21. Chem Commun (Camb). 2011. PMID: 22022702
A sydnone cycloaddition route to pyrazole boronic esters.
Browne DL, Helm MD, Plant A, Harrity JP. Browne DL, et al. Among authors: helm md. Angew Chem Int Ed Engl. 2007;46(45):8656-8. doi: 10.1002/anie.200703767. Angew Chem Int Ed Engl. 2007. PMID: 17918173 No abstract available.
14 results