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METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer.
García-Vílchez R, Añazco-Guenkova AM, Dietmann S, López J, Morón-Calvente V, D'Ambrosi S, Nombela P, Zamacola K, Mendizabal I, García-Longarte S, Zabala-Letona A, Astobiza I, Fernández S, Paniagua A, Miguel-López B, Marchand V, Alonso-López D, Merkel A, García-Tuñón I, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Azkargorta M, Elortza F, Bárcena L, Gonzalez-Lopez M, Aransay AM, Di Domenico T, Sánchez-Martín MA, De Las Rivas J, Guil S, Motorin Y, Helm M, Pandolfi PP, Carracedo A, Blanco S. García-Vílchez R, et al. Among authors: helm m. Mol Cancer. 2023 Jul 29;22(1):119. doi: 10.1186/s12943-023-01809-8. Mol Cancer. 2023. PMID: 37516825 Free PMC article.
Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines.
Pichot F, Hogg MC, Marchand V, Bourguignon V, Jirström E, Farrell C, Gibriel HA, Prehn JHM, Motorin Y, Helm M. Pichot F, et al. Among authors: helm m. Comput Struct Biotechnol J. 2022 Dec 19;21:401-417. doi: 10.1016/j.csbj.2022.12.020. eCollection 2023. Comput Struct Biotechnol J. 2022. PMID: 36618980 Free PMC article.
N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer's disease.
Jörg M, Plehn JE, Kristen M, Lander M, Walz L, Lietz C, Wijns J, Pichot F, Rojas-Charry L, Wirtz Martin KM, Ruffini N, Kreim N, Gerber S, Motorin Y, Endres K, Rossmanith W, Methner A, Helm M, Friedland K. Jörg M, et al. Among authors: helm m. Mol Psychiatry. 2024 Jan 29. doi: 10.1038/s41380-024-02421-y. Online ahead of print. Mol Psychiatry. 2024. PMID: 38287100
Fluoropyrimidines trigger decay of hypomodified tRNA in yeast.
Görlitz K, Bessler L, Helm M, Schaffrath R, Klassen R. Görlitz K, et al. Among authors: helm m. Nucleic Acids Res. 2024 May 8:gkae341. doi: 10.1093/nar/gkae341. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38716877
724 results