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Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.
Zhang L, Simonsen C, Zimova L, Wang K, Moparthi L, Gaudet R, Ekoff M, Nilsson G, Hellmich UA, Vlachova V, Gourdon P, Zygmunt PM. Zhang L, et al. Among authors: hellmich ua. Nat Commun. 2022 Dec 5;13(1):7483. doi: 10.1038/s41467-022-35163-y. Nat Commun. 2022. PMID: 36470868 Free PMC article.
Structural biology of TRP channels.
Hellmich UA, Gaudet R. Hellmich UA, et al. Handb Exp Pharmacol. 2014;223:963-90. doi: 10.1007/978-3-319-05161-1_10. Handb Exp Pharmacol. 2014. PMID: 24961976 Free PMC article. Review.
Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity.
Goretzki B, Wiedemann C, McCray BA, Schäfer SL, Jansen J, Tebbe F, Mitrovic SA, Nöth J, Cabezudo AC, Donohue JK, Jeffries CM, Steinchen W, Stengel F, Sumner CJ, Hummer G, Hellmich UA. Goretzki B, et al. Among authors: hellmich ua. Nat Commun. 2023 Jul 13;14(1):4165. doi: 10.1038/s41467-023-39808-4. Nat Commun. 2023. PMID: 37443299 Free PMC article.
Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold.
Catalina-Hernández È, López-Martín M, Masnou-Sánchez D, Martins M, Lorenz-Fonfria VA, Jiménez-Altayó F, Hellmich UA, Inada H, Alcaraz A, Furutani Y, Nonell-Canals A, Vázquez-Ibar JL, Domene C, Gaudet R, Perálvarez-Marín A. Catalina-Hernández È, et al. Among authors: hellmich ua. Comput Struct Biotechnol J. 2023 Dec 29;23:473-482. doi: 10.1016/j.csbj.2023.12.028. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38261868 Free PMC article.
Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli.
Garcia-Elias A, Mrkonjic S, Pardo-Pastor C, Inada H, Hellmich UA, Rubio-Moscardó F, Plata C, Gaudet R, Vicente R, Valverde MA. Garcia-Elias A, et al. Among authors: hellmich ua. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9553-8. doi: 10.1073/pnas.1220231110. Epub 2013 May 20. Proc Natl Acad Sci U S A. 2013. PMID: 23690576 Free PMC article.
71 results