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TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells.
Alpizar YA, Boonen B, Sanchez A, Jung C, López-Requena A, Naert R, Steelant B, Luyts K, Plata C, De Vooght V, Vanoirbeek JAJ, Meseguer VM, Voets T, Alvarez JL, Hellings PW, Hoet PHM, Nemery B, Valverde MA, Talavera K. Alpizar YA, et al. Among authors: hellings pw. Nat Commun. 2017 Oct 20;8(1):1059. doi: 10.1038/s41467-017-01201-3. Nat Commun. 2017. PMID: 29057902 Free PMC article.
Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice.
Hox V, Vanoirbeek JA, Alpizar YA, Voedisch S, Callebaut I, Bobic S, Sharify A, De Vooght V, Van Gerven L, Devos F, Liston A, Voets T, Vennekens R, Bullens DM, De Vries A, Hoet P, Braun A, Ceuppens JL, Talavera K, Nemery B, Hellings PW. Hox V, et al. Among authors: hellings pw. Am J Respir Crit Care Med. 2013 Mar 1;187(5):486-93. doi: 10.1164/rccm.201208-1358OC. Epub 2012 Dec 21. Am J Respir Crit Care Med. 2013. PMID: 23262517
Epithelial barriers in allergy and asthma.
Hellings PW, Steelant B. Hellings PW, et al. J Allergy Clin Immunol. 2020 Jun;145(6):1499-1509. doi: 10.1016/j.jaci.2020.04.010. J Allergy Clin Immunol. 2020. PMID: 32507228 Free PMC article. Review.
Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis.
Van Gerven L, Alpizar YA, Wouters MM, Hox V, Hauben E, Jorissen M, Boeckxstaens G, Talavera K, Hellings PW. Van Gerven L, et al. Among authors: hellings pw. J Allergy Clin Immunol. 2014 May;133(5):1332-9, 1339.e1-3. doi: 10.1016/j.jaci.2013.08.026. Epub 2013 Oct 15. J Allergy Clin Immunol. 2014. PMID: 24139494
Enhanced chemosensory sensitivity in patients with idiopathic rhinitis and its reversal by nasal capsaicin treatment.
Van Gerven L, Alpizar YA, Steelant B, Callebaut I, Kortekaas Krohn I, Wouters M, Vermeulen F, Boeckxstaens G, Talavera K, Hellings PW. Van Gerven L, et al. Among authors: hellings pw. J Allergy Clin Immunol. 2017 Aug;140(2):437-446.e2. doi: 10.1016/j.jaci.2017.03.014. Epub 2017 Apr 4. J Allergy Clin Immunol. 2017. PMID: 28389389 Clinical Trial.
Histamine and T helper cytokine-driven epithelial barrier dysfunction in allergic rhinitis.
Steelant B, Seys SF, Van Gerven L, Van Woensel M, Farré R, Wawrzyniak P, Kortekaas Krohn I, Bullens DM, Talavera K, Raap U, Boon L, Akdis CA, Boeckxstaens G, Ceuppens JL, Hellings PW. Steelant B, et al. Among authors: hellings pw. J Allergy Clin Immunol. 2018 Mar;141(3):951-963.e8. doi: 10.1016/j.jaci.2017.08.039. Epub 2017 Oct 23. J Allergy Clin Immunol. 2018. PMID: 29074456 Free article. Clinical Trial.
Epithelial and sensory mechanisms of nasal hyperreactivity.
Velasco E, Delicado-Miralles M, Hellings PW, Gallar J, Van Gerven L, Talavera K. Velasco E, et al. Among authors: hellings pw. Allergy. 2022 May;77(5):1450-1463. doi: 10.1111/all.15259. Epub 2022 Feb 26. Allergy. 2022. PMID: 35174893 Review.
Blocking histone deacetylase activity as a novel target for epithelial barrier defects in patients with allergic rhinitis.
Steelant B, Wawrzyniak P, Martens K, Jonckheere AC, Pugin B, Schrijvers R, Bullens DM, Vanoirbeek JA, Krawczyk K, Dreher A, Akdis CA, Hellings PW. Steelant B, et al. Among authors: hellings pw. J Allergy Clin Immunol. 2019 Nov;144(5):1242-1253.e7. doi: 10.1016/j.jaci.2019.04.027. Epub 2019 May 11. J Allergy Clin Immunol. 2019. PMID: 31082457
315 results