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Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Green AC, Marttila P, Kiweler N, Chalkiadaki C, Wiita E, Cookson V, Lesur A, Eiden K, Bernardin F, Vallin KSA, Borhade S, Long M, Ghahe EK, Jiménez-Alonso JJ, Jemth AS, Loseva O, Mortusewicz O, Meyers M, Viry E, Johansson AI, Hodek O, Homan E, Bonagas N, Ramos L, Sandberg L, Frödin M, Moussay E, Slipicevic A, Letellier E, Paggetti J, Sørensen CS, Helleday T, Henriksson M, Meiser J. Green AC, et al. Among authors: helleday t. Nat Metab. 2023 Apr;5(4):642-659. doi: 10.1038/s42255-023-00771-5. Epub 2023 Apr 3. Nat Metab. 2023. PMID: 37012496 Free PMC article.
The histone methyltransferase SET8 is required for S-phase progression.
Jørgensen S, Elvers I, Trelle MB, Menzel T, Eskildsen M, Jensen ON, Helleday T, Helin K, Sørensen CS. Jørgensen S, et al. Among authors: helleday t. J Cell Biol. 2007 Dec 31;179(7):1337-45. doi: 10.1083/jcb.200706150. J Cell Biol. 2007. PMID: 18166648 Free PMC article.
Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.
Lehtiö L, Jemth AS, Collins R, Loseva O, Johansson A, Markova N, Hammarström M, Flores A, Holmberg-Schiavone L, Weigelt J, Helleday T, Schüler H, Karlberg T. Lehtiö L, et al. Among authors: helleday t. J Med Chem. 2009 May 14;52(9):3108-11. doi: 10.1021/jm900052j. J Med Chem. 2009. PMID: 19354255
Crystal structure of human MTH1 and the 8-oxo-dGMP product complex.
Svensson LM, Jemth AS, Desroses M, Loseva O, Helleday T, Högbom M, Stenmark P. Svensson LM, et al. Among authors: helleday t. FEBS Lett. 2011 Aug 19;585(16):2617-21. doi: 10.1016/j.febslet.2011.07.017. Epub 2011 Jul 23. FEBS Lett. 2011. PMID: 21787772 Free article.
Castration therapy results in decreased Ku70 levels in prostate cancer.
Al-Ubaidi FL, Schultz N, Loseva O, Egevad L, Granfors T, Helleday T. Al-Ubaidi FL, et al. Among authors: helleday t. Clin Cancer Res. 2013 Mar 15;19(6):1547-56. doi: 10.1158/1078-0432.CCR-12-2795. Epub 2013 Jan 24. Clin Cancer Res. 2013. PMID: 23349316
293 results