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Page 1
Pharmacological OGG1 inhibition decreases murine allergic airway inflammation.
Tanner L, Bergwik J, Bhongir RKV, Pan L, Dong C, Wallner O, Kalderén C, Helleday T, Boldogh I, Adner M, Egesten A. Tanner L, et al. Among authors: helleday t. Front Pharmacol. 2022 Oct 17;13:999180. doi: 10.3389/fphar.2022.999180. eCollection 2022. Front Pharmacol. 2022. PMID: 36324676 Free PMC article.
Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming.
Pateras IS, Williams C, Gianniou DD, Margetis AT, Avgeris M, Rousakis P, Legaki AI, Mirtschink P, Zhang W, Panoutsopoulou K, Delis AD, Pagakis SN, Tang W, Ambs S, Warpman Berglund U, Helleday T, Varvarigou A, Chatzigeorgiou A, Nordström A, Tsitsilonis OE, Trougakos IP, Gilthorpe JD, Frisan T. Pateras IS, et al. Among authors: helleday t. J Transl Med. 2023 Mar 3;21(1):169. doi: 10.1186/s12967-023-03935-9. J Transl Med. 2023. PMID: 36869333 Free PMC article.
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.
Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG. Zhang SM, et al. Among authors: helleday t. iScience. 2024 Jan 13;27(2):108907. doi: 10.1016/j.isci.2024.108907. eCollection 2024 Feb 16. iScience. 2024. PMID: 38318365 Free PMC article.
Ex-vivo drug screening of surgically resected glioma stem cells to replace murine avatars and provide personalise cancer therapy for glioblastoma patients.
Gagg H, Williams ST, Conroy S, Myers KN, McGarrity-Cottrell C, Jones C, Helleday T, Rantala J, Rominiyi O, Danson SJ, Collis SJ, Wells G. Gagg H, et al. Among authors: helleday t. F1000Res. 2024 Mar 11;12:954. doi: 10.12688/f1000research.135809.1. eCollection 2023. F1000Res. 2024. PMID: 37799492 Free PMC article.
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue.
Zhang N, Harbers L, Simonetti M, Diekmann C, Verron Q, Berrino E, Bellomo SE, Longo GMC, Ratz M, Schultz N, Tarish F, Su P, Han B, Wang W, Onorato S, Grassini D, Ballarino R, Giordano S, Yang Q, Sapino A, Frisén J, Alkass K, Druid H, Roukos V, Helleday T, Marchiò C, Bienko M, Crosetto N. Zhang N, et al. Among authors: helleday t. Nat Commun. 2024 Apr 24;15(1):3475. doi: 10.1038/s41467-024-47664-z. Nat Commun. 2024. PMID: 38658552 Free PMC article.
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation.
Marttila P, Bonagas N, Chalkiadaki C, Stigsdotter H, Schelzig K, Shen J, Farhat CM, Hondema A, Albers J, Wiita E, Rasti A, Warpman Berglund U, Slipicevic A, Mortusewicz O, Helleday T. Marttila P, et al. Among authors: helleday t. Mol Oncol. 2024 Mar 27. doi: 10.1002/1878-0261.13645. Online ahead of print. Mol Oncol. 2024. PMID: 38533616 Free article.
293 results