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PR-DUB safeguards Polycomb repression through H2AK119ub1 restriction.
Li R, Huang D, Zhao Y, Yuan Y, Sun X, Dai Z, Huo D, Liu X, Helin K, Li MJ, Wu X. Li R, et al. Among authors: helin k. Cell Prolif. 2023 Oct;56(10):e13457. doi: 10.1111/cpr.13457. Epub 2023 Mar 23. Cell Prolif. 2023. PMID: 36959757 Free PMC article.
Discovery of NSD2-Degraders from Novel and Selective DEL Hits.
LegaardAndersson J, Christensen J, Kleine-Kohlbrecher D, Vacher Comet I, Fullerton Støier J, Antoku Y, Poljak V, Moretti L, Dolberg J, Jacso T, Jensby Nielsen S, Nørregaard-Madsen M, Franch T, Helin K, Cloos PAC. LegaardAndersson J, et al. Among authors: helin k. Chembiochem. 2023 Dec 14;24(24):e202300515. doi: 10.1002/cbic.202300515. Epub 2023 Oct 24. Chembiochem. 2023. PMID: 37807669
Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation.
Cheng KCL, Frost JM, Sánchez-Luque FJ, García-Canãdas M, Taylor D, Yang WR, Irayanar B, Sampath S, Patani H, Agger K, Helin K, Ficz G, Burns KH, Ewing A, García-Pérez JL, Branco MR. Cheng KCL, et al. Among authors: helin k. Epigenetics Chromatin. 2023 Oct 16;16(1):39. doi: 10.1186/s13072-023-00514-6. Epigenetics Chromatin. 2023. PMID: 37845773 Free PMC article.
Correction: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation.
Grassilli E, Pisano F, Cialdella A, Bonomo S, Missaglia C, Cerrito MG, Masiero L, Ianzano L, Giordano F, Cicirelli V, Narloch R, D'Amato F, Noli B, Ferri GL, Leone BE, Stanta G, Bonin S, Helin K, Giovannoni R, Lavitrano M. Grassilli E, et al. Among authors: helin k. Oncogene. 2024 Apr 18. doi: 10.1038/s41388-024-03037-w. Online ahead of print. Oncogene. 2024. PMID: 38637670 No abstract available.
TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers.
Damhofer H, Tatar T, Southgate B, Scarneo S, Agger K, Shlyueva D, Uhrbom L, Morrison GM, Hughes PF, Haystead T, Pollard SM, Helin K. Damhofer H, et al. Among authors: helin k. Cell Death Dis. 2024 Apr 17;15(4):273. doi: 10.1038/s41419-024-06654-1. Cell Death Dis. 2024. PMID: 38632238 Free PMC article.
RIO-kinase 2 is essential for hematopoiesis.
Messling JE, Peña-Rømer I, Moroni AS, Bruestl S, Helin K. Messling JE, et al. Among authors: helin k. PLoS One. 2024 Apr 2;19(4):e0300623. doi: 10.1371/journal.pone.0300623. eCollection 2024. PLoS One. 2024. PMID: 38564577 Free PMC article.
305 results