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The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.
Karousou E, Kamiryo M, Skandalis SS, Ruusala A, Asteriou T, Passi A, Yamashita H, Hellman U, Heldin CH, Heldin P. Karousou E, et al. Among authors: heldin p, heldin ch. J Biol Chem. 2010 Jul 30;285(31):23647-54. doi: 10.1074/jbc.M110.127050. Epub 2010 May 27. J Biol Chem. 2010. PMID: 20507985 Free PMC article.
Hyaluronan synthesis is inhibited by adenosine monophosphate-activated protein kinase through the regulation of HAS2 activity in human aortic smooth muscle cells.
Vigetti D, Clerici M, Deleonibus S, Karousou E, Viola M, Moretto P, Heldin P, Hascall VC, De Luca G, Passi A. Vigetti D, et al. Among authors: heldin p. J Biol Chem. 2011 Mar 11;286(10):7917-7924. doi: 10.1074/jbc.M110.193656. Epub 2011 Jan 12. J Biol Chem. 2011. PMID: 21228273 Free PMC article.
HAS2 and CD44 in breast tumorigenesis.
Heldin P, Basu K, Kozlova I, Porsch H. Heldin P, et al. Adv Cancer Res. 2014;123:211-29. doi: 10.1016/B978-0-12-800092-2.00008-3. Adv Cancer Res. 2014. PMID: 25081531 Review.
87 results