Heitman LH - Search Results

1

A multiple classifier system identifies novel cannabinoid CB2 receptor ligands.

Ruano-Ordás D, Burggraaff L, Liu R, van der Horst C, Heitman LH, Emmerich MTM, Mendez JR, Yevseyeva I, van Westen GJP. Ruano-Ordás D, et al. Among authors: heitman lh. J Cheminform. 2019 Nov 7;11(1):66. doi: 10.1186/s13321-019-0389-9. J Cheminform. 2019. PMID: 33430920 Free PMC article.

2

Molecular Basis of Ligand Dissociation from the Adenosine A2A Receptor.

Guo D, Pan AC, Dror RO, Mocking T, Liu R, Heitman LH, Shaw DE, IJzerman AP. Guo D, et al. Among authors: heitman lh. Mol Pharmacol. 2016 May;89(5):485-91. doi: 10.1124/mol.115.102657. Epub 2016 Feb 12. Mol Pharmacol. 2016. PMID: 26873858

3

Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms.

Jespers W, Schiedel AC, Heitman LH, Cooke RM, Kleene L, van Westen GJP, Gloriam DE, Müller CE, Sotelo E, Gutiérrez-de-Terán H. Jespers W, et al. Among authors: heitman lh. Trends Pharmacol Sci. 2018 Jan;39(1):75-89. doi: 10.1016/j.tips.2017.11.001. Epub 2017 Dec 5. Trends Pharmacol Sci. 2018. PMID: 29203139 Review.

4

Characterization of cancer-related somatic mutations in the adenosine A_2B receptor.

Wang X, Jespers W, Bongers BJ, Habben Jansen MCC, Stangenberger CM, Dilweg MA, Gutiérrez-de-Terán H, IJzerman AP, Heitman LH, van Westen GJP. Wang X, et al. Among authors: heitman lh. Eur J Pharmacol. 2020 Aug 5;880:173126. doi: 10.1016/j.ejphar.2020.173126. Epub 2020 Apr 26. Eur J Pharmacol. 2020. PMID: 32348778 Free article.

5

Design and pharmacological profile of a novel covalent partial agonist for the adenosine A₁ receptor.

Yang X, Dilweg MA, Osemwengie D, Burggraaff L, van der Es D, Heitman LH, IJzerman AP. Yang X, et al. Among authors: heitman lh. Biochem Pharmacol. 2020 Oct;180:114144. doi: 10.1016/j.bcp.2020.114144. Epub 2020 Jul 10. Biochem Pharmacol. 2020. PMID: 32653590 Free article.

6

G protein-coupled receptors expressed and studied in yeast. The adenosine receptor as a prime example.

Wang X, van Westen GJP, Heitman LH, IJzerman AP. Wang X, et al. Among authors: heitman lh. Biochem Pharmacol. 2021 May;187:114370. doi: 10.1016/j.bcp.2020.114370. Epub 2020 Dec 16. Biochem Pharmacol. 2021. PMID: 33338473 Free article. Review.

7

Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2.

Ortiz Zacarías NV, Chahal KK, Šimková T, van der Horst C, Zheng Y, Inoue A, Theunissen E, Mallee L, van der Es D, Louvel J, IJzerman AP, Handel TM, Kufareva I, Heitman LH. Ortiz Zacarías NV, et al. Among authors: heitman lh. J Med Chem. 2021 Mar 11;64(5):2608-2621. doi: 10.1021/acs.jmedchem.0c01137. Epub 2021 Feb 18. J Med Chem. 2021. PMID: 33600174 Free PMC article.

8

Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A_2A Receptor.

Amelia T, van Veldhoven JPD, Falsini M, Liu R, Heitman LH, van Westen GJP, Segala E, Verdon G, Cheng RKY, Cooke RM, van der Es D, IJzerman AP. Amelia T, et al. Among authors: heitman lh. J Med Chem. 2021 Apr 8;64(7):3827-3842. doi: 10.1021/acs.jmedchem.0c01856. Epub 2021 Mar 25. J Med Chem. 2021. PMID: 33764785 Free PMC article.

9

Synthesis and SAR evaluation of coumarin derivatives as potent cannabinoid receptor agonists.

Mohr F, Hurrle T, Burggraaff L, Langer L, Bemelmans MP, Knab M, Nieger M, van Westen GJP, Heitman LH, Bräse S. Mohr F, et al. Among authors: heitman lh. Eur J Med Chem. 2021 Aug 5;220:113354. doi: 10.1016/j.ejmech.2021.113354. Epub 2021 Apr 7. Eur J Med Chem. 2021. PMID: 33915369

10

Identification of V6.51L as a selectivity hotspot in stereoselective A_2B adenosine receptor antagonist recognition.

Wang X, Jespers W, Prieto-Díaz R, Majellaro M, IJzerman AP, van Westen GJP, Sotelo E, Heitman LH, Gutiérrez-de-Terán H. Wang X, et al. Among authors: heitman lh. Sci Rep. 2021 Jul 8;11(1):14171. doi: 10.1038/s41598-021-93419-x. Sci Rep. 2021. PMID: 34238993 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

145 results

Search Page