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Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes.
J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581. Epub 2023 Dec 22.
J Am Chem Soc. 2024.
PMID: 38134034
Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Warrington S, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM.
Ramsey JR, et al. Among authors: heiss tk.
bioRxiv [Preprint]. 2023 Sep 26:2023.09.25.559391. doi: 10.1101/2023.09.25.559391.
bioRxiv. 2023.
PMID: 37808863
Free PMC article.
Updated.
Preprint.
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Fluorogenic Cyclopropenones for Multicomponent, Real-Time Imaging.
Heiss TK, Dorn RS, Ferreira AJ, Love AC, Prescher JA.
Heiss TK, et al.
J Am Chem Soc. 2022 May 4;144(17):7871-7880. doi: 10.1021/jacs.2c02058. Epub 2022 Apr 20.
J Am Chem Soc. 2022.
PMID: 35442034
Free PMC article.
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Bioorthogonal Reactions of Triarylphosphines and Related Analogues.
Heiss TK, Dorn RS, Prescher JA.
Heiss TK, et al.
Chem Rev. 2021 Jun 23;121(12):6802-6849. doi: 10.1021/acs.chemrev.1c00014. Epub 2021 Jun 8.
Chem Rev. 2021.
PMID: 34101453
Free PMC article.
Review.
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Butenolide Synthesis from Functionalized Cyclopropenones.
Nguyen SS, Ferreira AJ, Long ZG, Heiss TK, Dorn RS, Row RD, Prescher JA.
Nguyen SS, et al. Among authors: heiss tk.
Org Lett. 2019 Nov 1;21(21):8695-8699. doi: 10.1021/acs.orglett.9b03298. Epub 2019 Oct 17.
Org Lett. 2019.
PMID: 31622107
Free PMC article.
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Cyclopropeniminium Ions Exhibit Unique Reactivity Profiles with Bioorthogonal Phosphines.
Heiss TK, Prescher JA.
Heiss TK, et al.
J Org Chem. 2019 Jun 7;84(11):7443-7448. doi: 10.1021/acs.joc.9b00518. Epub 2019 May 28.
J Org Chem. 2019.
PMID: 31083911
Free PMC article.
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Postsynthetic Modification of Bacterial Peptidoglycan Using Bioorthogonal N-Acetylcysteamine Analogs and Peptidoglycan O-Acetyltransferase B.
Wang Y, Lazor KM, DeMeester KE, Liang H, Heiss TK, Grimes CL.
Wang Y, et al. Among authors: heiss tk.
J Am Chem Soc. 2017 Oct 4;139(39):13596-13599. doi: 10.1021/jacs.7b06820. Epub 2017 Sep 26.
J Am Chem Soc. 2017.
PMID: 28898061
Free PMC article.
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