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Mapping the cellular response to small molecules using chemogenomic fitness signatures.
Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G. Lee AY, et al. Among authors: heisler le. Science. 2014 Apr 11;344(6180):208-11. doi: 10.1126/science.1250217. Science. 2014. PMID: 24723613 Free PMC article.
Quantitative phenotyping via deep barcode sequencing.
Smith AM, Heisler LE, Mellor J, Kaper F, Thompson MJ, Chee M, Roth FP, Giaever G, Nislow C. Smith AM, et al. Among authors: heisler le. Genome Res. 2009 Oct;19(10):1836-42. doi: 10.1101/gr.093955.109. Epub 2009 Jul 21. Genome Res. 2009. PMID: 19622793 Free PMC article.
Genotype to phenotype: a complex problem.
Dowell RD, Ryan O, Jansen A, Cheung D, Agarwala S, Danford T, Bernstein DA, Rolfe PA, Heisler LE, Chin B, Nislow C, Giaever G, Phillips PC, Fink GR, Gifford DK, Boone C. Dowell RD, et al. Among authors: heisler le. Science. 2010 Apr 23;328(5977):469. doi: 10.1126/science.1189015. Science. 2010. PMID: 20413493 Free PMC article.
A comprehensive platform for highly multiplexed mammalian functional genetic screens.
Ketela T, Heisler LE, Brown KR, Ammar R, Kasimer D, Surendra A, Ericson E, Blakely K, Karamboulas D, Smith AM, Durbic T, Arnoldo A, Cheung-Ong K, Koh JL, Gopal S, Cowley GS, Yang X, Grenier JK, Giaever G, Root DE, Moffat J, Nislow C. Ketela T, et al. Among authors: heisler le. BMC Genomics. 2011 May 6;12:213. doi: 10.1186/1471-2164-12-213. BMC Genomics. 2011. PMID: 21548937 Free PMC article.
Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell.
Magtanong L, Ho CH, Barker SL, Jiao W, Baryshnikova A, Bahr S, Smith AM, Heisler LE, Choy JS, Kuzmin E, Andrusiak K, Kobylianski A, Li Z, Costanzo M, Basrai MA, Giaever G, Nislow C, Andrews B, Boone C. Magtanong L, et al. Among authors: heisler le. Nat Biotechnol. 2011 May 15;29(6):505-11. doi: 10.1038/nbt.1855. Nat Biotechnol. 2011. PMID: 21572441 Free PMC article.
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