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Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation.
de Jonckheere B, Kollotzek F, Münzer P, Göb V, Fischer M, Mott K, Coman C, Troppmair NN, Manke MC, Zdanyte M, Harm T, Sigle M, Kopczynski D, Bileck A, Gerner C, Hoffmann N, Heinzmann D, Assinger A, Gawaz M, Stegner D, Schulze H, Borst O, Ahrends R. de Jonckheere B, et al. Among authors: heinzmann d. Nat Cardiovasc Res. 2023 Sep;2:835-852. doi: 10.1038/s44161-023-00325-8. Epub 2023 Aug 31. Nat Cardiovasc Res. 2023. PMID: 38075556 Free PMC article.
Extracellular cyclophilin A activates platelets via EMMPRIN (CD147) and PI3K/Akt signaling, which promotes platelet adhesion and thrombus formation in vitro and in vivo.
Seizer P, Ungern-Sternberg SN, Schönberger T, Borst O, Münzer P, Schmidt EM, Mack AF, Heinzmann D, Chatterjee M, Langer H, Malešević M, Lang F, Gawaz M, Fischer G, May AE. Seizer P, et al. Among authors: heinzmann d. Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):655-63. doi: 10.1161/ATVBAHA.114.305112. Epub 2014 Dec 30. Arterioscler Thromb Vasc Biol. 2015. PMID: 25550208
Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation.
von Ungern-Sternberg SNI, Vogel S, Walker-Allgaier B, Geue S, Maurer A, Wild AM, Münzer P, Chatterjee M, Heinzmann D, Kremmer E, Borst O, Loughran P, Zernecke A, Neal MD, Billiar TR, Gawaz M, Seizer P. von Ungern-Sternberg SNI, et al. Among authors: heinzmann d. Thromb Haemost. 2017 Nov;117(11):2063-2078. doi: 10.1160/TH17-01-0067. Epub 2017 Nov 30. Thromb Haemost. 2017. PMID: 28981554 Free PMC article.
Platelet surface expression of cyclophilin A is associated with increased mortality in patients with symptomatic coronary artery disease.
Rath D, von Ungern-Sternberg S, Heinzmann D, Sigle M, Monzien M, Horstmann K, Schaeffeler E, Winter S, Müller K, Groga-Bada P, Zdanyte M, Borst O, Zernecke A, Gawaz M, Martus P, Schwab M, Geisler T, Seizer P. Rath D, et al. Among authors: heinzmann d. J Thromb Haemost. 2020 Jan;18(1):234-242. doi: 10.1111/jth.14635. Epub 2019 Oct 20. J Thromb Haemost. 2020. PMID: 31519036 Free article.
Deceleration capacity is associated with acute respiratory distress syndrome in COVID-19.
Mizera L, Rath D, Schoellmann A, Petersen-Uribe A, Avdiu A, Zdanyte M, Jaeger P, Heinzmann D, Müller K, Gawaz M, Eick C, Duckheim M. Mizera L, et al. Among authors: heinzmann d. Heart Lung. 2021 Nov-Dec;50(6):914-918. doi: 10.1016/j.hrtlng.2021.07.016. Epub 2021 Aug 2. Heart Lung. 2021. PMID: 34428736 Free PMC article.
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury.
Rohlfing AK, Kolb K, Sigle M, Ziegler M, Bild A, Münzer P, Sudmann J, Dicenta V, Harm T, Manke MC, Geue S, Kremser M, Chatterjee M, Liang C, von Eysmondt H, Dandekar T, Heinzmann D, Günter M, von Ungern-Sternberg S, Büttcher M, Castor T, Mencl S, Langhauser F, Sies K, Ashour D, Beker MC, Lämmerhofer M, Autenrieth SE, Schäffer TE, Laufer S, Szklanna P, Maguire P, Heikenwalder M, Müller KAL, Hermann DM, Kilic E, Stumm R, Ramos G, Kleinschnitz C, Borst O, Langer HF, Rath D, Gawaz M. Rohlfing AK, et al. Among authors: heinzmann d. Nat Commun. 2022 Apr 5;13(1):1823. doi: 10.1038/s41467-022-29341-1. Nat Commun. 2022. PMID: 35383158 Free PMC article.
62 results