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The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites.
Bean C, Audano M, Varanita T, Favaretto F, Medaglia M, Gerdol M, Pernas L, Stasi F, Giacomello M, Herkenne S, Muniandy M, Heinonen S, Cazaly E, Ollikainen M, Milan G, Pallavicini A, Pietiläinen KH, Vettor R, Mitro N, Scorrano L. Bean C, et al. Among authors: heinonen s. Nat Metab. 2021 Dec;3(12):1633-1647. doi: 10.1038/s42255-021-00497-2. Epub 2021 Dec 6. Nat Metab. 2021. PMID: 34873337 Free article.
Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity.
Heinonen S, Buzkova J, Muniandy M, Kaksonen R, Ollikainen M, Ismail K, Hakkarainen A, Lundbom J, Lundbom N, Vuolteenaho K, Moilanen E, Kaprio J, Rissanen A, Suomalainen A, Pietiläinen KH. Heinonen S, et al. Diabetes. 2015 Sep;64(9):3135-45. doi: 10.2337/db14-1937. Epub 2015 May 13. Diabetes. 2015. PMID: 25972572
Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins.
Jukarainen S, Heinonen S, Rämö JT, Rinnankoski-Tuikka R, Rappou E, Tummers M, Muniandy M, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Pirinen E, Pietiläinen KH. Jukarainen S, et al. Among authors: heinonen s. J Clin Endocrinol Metab. 2016 Jan;101(1):275-83. doi: 10.1210/jc.2015-3095. Epub 2015 Nov 17. J Clin Endocrinol Metab. 2016. PMID: 26574954
Weight Loss Is Associated With Increased NAD(+)/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue.
Rappou E, Jukarainen S, Rinnankoski-Tuikka R, Kaye S, Heinonen S, Hakkarainen A, Lundbom J, Lundbom N, Saunavaara V, Rissanen A, Virtanen KA, Pirinen E, Pietiläinen KH. Rappou E, et al. Among authors: heinonen s. J Clin Endocrinol Metab. 2016 Mar;101(3):1263-73. doi: 10.1210/jc.2015-3054. Epub 2016 Jan 13. J Clin Endocrinol Metab. 2016. PMID: 26760174 Clinical Trial.
Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Subcutaneous Adipose Tissue and Adipocytes in Acquired Obesity.
Kaye S, Lokki AI, Hanttu A, Nissilä E, Heinonen S, Hakkarainen A, Lundbom J, Lundbom N, Saarinen L, Tynninen O, Muniandy M, Rissanen A, Kaprio J, Meri S, Pietiläinen KH. Kaye S, et al. Among authors: heinonen s. Front Immunol. 2017 May 16;8:545. doi: 10.3389/fimmu.2017.00545. eCollection 2017. Front Immunol. 2017. PMID: 28559893 Free PMC article.
Metabolism of sex steroids is influenced by acquired adiposity-A study of young adult male monozygotic twin pairs.
Vihma V, Naukkarinen J, Turpeinen U, Hämäläinen E, Kaprio J, Rissanen A, Heinonen S, Hakkarainen A, Lundbom J, Lundbom N, Mikkola TS, Tikkanen MJ, Pietiläinen KH. Vihma V, et al. Among authors: heinonen s. J Steroid Biochem Mol Biol. 2017 Sep;172:98-105. doi: 10.1016/j.jsbmb.2017.06.007. Epub 2017 Jun 13. J Steroid Biochem Mol Biol. 2017. PMID: 28619249
Increased body fat mass and androgen metabolism - A twin study in healthy young women.
Vihma V, Heinonen S, Naukkarinen J, Kaprio J, Rissanen A, Turpeinen U, Hämäläinen E, Hakkarainen A, Lundbom J, Lundbom N, Mikkola TS, Tikkanen MJ, Pietiläinen KH. Vihma V, et al. Among authors: heinonen s. Steroids. 2018 Dec;140:24-31. doi: 10.1016/j.steroids.2018.08.006. Epub 2018 Aug 25. Steroids. 2018. PMID: 30149073
The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance.
Miao Z, Alvarez M, Ko A, Bhagat Y, Rahmani E, Jew B, Heinonen S, Muñoz-Hernandez LL, Herrera-Hernandez M, Aguilar-Salinas C, Tusie-Luna T, Mohlke KL, Laakso M, Pietiläinen KH, Halperin E, Pajukanta P. Miao Z, et al. Among authors: heinonen s. PLoS Genet. 2020 Sep 14;16(9):e1009018. doi: 10.1371/journal.pgen.1009018. eCollection 2020 Sep. PLoS Genet. 2020. PMID: 32925908 Free PMC article.
490 results