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Should losartan be administered following brain injury?
Friedman A, Bar-Klein G, Serlin Y, Parmet Y, Heinemann U, Kaufer D. Friedman A, et al. Among authors: heinemann u. Expert Rev Neurother. 2014 Dec;14(12):1365-75. doi: 10.1586/14737175.2014.972945. Epub 2014 Oct 27. Expert Rev Neurother. 2014. PMID: 25346269 Review.
Losartan prevents acquired epilepsy via TGF-β signaling suppression.
Bar-Klein G, Cacheaux LP, Kamintsky L, Prager O, Weissberg I, Schoknecht K, Cheng P, Kim SY, Wood L, Heinemann U, Kaufer D, Friedman A. Bar-Klein G, et al. Among authors: heinemann u. Ann Neurol. 2014 Jun;75(6):864-75. doi: 10.1002/ana.24147. Epub 2014 May 28. Ann Neurol. 2014. PMID: 24659129 Free PMC article.
Epileptiform activity and spreading depolarization in the blood-brain barrier-disrupted peri-infarct hippocampus are associated with impaired GABAergic inhibition and synaptic plasticity.
Lippmann K, Kamintsky L, Kim SY, Lublinsky S, Prager O, Nichtweiss JF, Salar S, Kaufer D, Heinemann U, Friedman A. Lippmann K, et al. Among authors: heinemann u. J Cereb Blood Flow Metab. 2017 May;37(5):1803-1819. doi: 10.1177/0271678X16652631. Epub 2016 Jan 1. J Cereb Blood Flow Metab. 2017. PMID: 27252228 Free PMC article.
TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults.
Kim SY, Senatorov VV Jr, Morrissey CS, Lippmann K, Vazquez O, Milikovsky DZ, Gu F, Parada I, Prince DA, Becker AJ, Heinemann U, Friedman A, Kaufer D. Kim SY, et al. Among authors: heinemann u. Sci Rep. 2017 Aug 9;7(1):7711. doi: 10.1038/s41598-017-07394-3. Sci Rep. 2017. PMID: 28794441 Free PMC article.
713 results