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Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis.
Ben-Othman N, Vieira A, Courtney M, Record F, Gjernes E, Avolio F, Hadzic B, Druelle N, Napolitano T, Navarro-Sanz S, Silvano S, Al-Hasani K, Pfeifer A, Lacas-Gervais S, Leuckx G, Marroquí L, Thévenet J, Madsen OD, Eizirik DL, Heimberg H, Kerr-Conte J, Pattou F, Mansouri A, Collombat P. Ben-Othman N, et al. Among authors: heimberg h. Cell. 2017 Jan 12;168(1-2):73-85.e11. doi: 10.1016/j.cell.2016.11.002. Epub 2016 Dec 1. Cell. 2017. PMID: 27916274 Free article.
Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P. Al-Hasani K, et al. Among authors: heimberg h. Dev Cell. 2013 Jul 15;26(1):86-100. doi: 10.1016/j.devcel.2013.05.018. Epub 2013 Jun 27. Dev Cell. 2013. PMID: 23810513 Free article.
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.
Courtney M, Gjernes E, Druelle N, Ravaud C, Vieira A, Ben-Othman N, Pfeifer A, Avolio F, Leuckx G, Lacas-Gervais S, Burel-Vandenbos F, Ambrosetti D, Hecksher-Sorensen J, Ravassard P, Heimberg H, Mansouri A, Collombat P. Courtney M, et al. Among authors: heimberg h. PLoS Genet. 2013 Oct;9(10):e1003934. doi: 10.1371/journal.pgen.1003934. Epub 2013 Oct 31. PLoS Genet. 2013. PMID: 24204325 Free PMC article.
Pancreatic beta-cells: from generation to regeneration.
Collombat P, Xu X, Heimberg H, Mansouri A. Collombat P, et al. Among authors: heimberg h. Semin Cell Dev Biol. 2010 Oct;21(8):838-44. doi: 10.1016/j.semcdb.2010.07.007. Epub 2010 Aug 3. Semin Cell Dev Biol. 2010. PMID: 20688184 Free PMC article. Review.
Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas.
Van de Casteele M, Leuckx G, Baeyens L, Cai Y, Yuchi Y, Coppens V, De Groef S, Eriksson M, Svensson C, Ahlgren U, Ahnfelt-Rønne J, Madsen OD, Waisman A, Dor Y, Jensen JN, Heimberg H. Van de Casteele M, et al. Among authors: heimberg h. Cell Death Dis. 2013 Mar 7;4(3):e523. doi: 10.1038/cddis.2013.52. Cell Death Dis. 2013. PMID: 23470530 Free PMC article.
Reversal of hyperglycemia in diabetic mice by a marginal islet mass together with human blood outgrowth endothelial cells is independent of the delivery technique and blood clot-induced processes.
Coppens V, Heremans Y, Leuckx G, Suenens K, Jacobs-Tulleneers-Thevissen D, Verdonck K, Luttun A, Heimberg H, De Leu N. Coppens V, et al. Among authors: heimberg h. Islets. 2013 Sep-Dec;5(5):196-200. doi: 10.4161/isl.26778. Epub 2013 Nov 8. Islets. 2013. PMID: 24213480 Free PMC article.
122 results