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Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P. Al-Hasani K, et al. Among authors: heimberg h. Dev Cell. 2013 Jul 15;26(1):86-100. doi: 10.1016/j.devcel.2013.05.018. Epub 2013 Jun 27. Dev Cell. 2013. PMID: 23810513 Free article.
Pancreatic beta-cells: from generation to regeneration.
Collombat P, Xu X, Heimberg H, Mansouri A. Collombat P, et al. Among authors: heimberg h. Semin Cell Dev Biol. 2010 Oct;21(8):838-44. doi: 10.1016/j.semcdb.2010.07.007. Epub 2010 Aug 3. Semin Cell Dev Biol. 2010. PMID: 20688184 Free PMC article. Review.
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.
Courtney M, Gjernes E, Druelle N, Ravaud C, Vieira A, Ben-Othman N, Pfeifer A, Avolio F, Leuckx G, Lacas-Gervais S, Burel-Vandenbos F, Ambrosetti D, Hecksher-Sorensen J, Ravassard P, Heimberg H, Mansouri A, Collombat P. Courtney M, et al. Among authors: heimberg h. PLoS Genet. 2013 Oct;9(10):e1003934. doi: 10.1371/journal.pgen.1003934. Epub 2013 Oct 31. PLoS Genet. 2013. PMID: 24204325 Free PMC article.
Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis.
Ben-Othman N, Vieira A, Courtney M, Record F, Gjernes E, Avolio F, Hadzic B, Druelle N, Napolitano T, Navarro-Sanz S, Silvano S, Al-Hasani K, Pfeifer A, Lacas-Gervais S, Leuckx G, Marroquí L, Thévenet J, Madsen OD, Eizirik DL, Heimberg H, Kerr-Conte J, Pattou F, Mansouri A, Collombat P. Ben-Othman N, et al. Among authors: heimberg h. Cell. 2017 Jan 12;168(1-2):73-85.e11. doi: 10.1016/j.cell.2016.11.002. Epub 2016 Dec 1. Cell. 2017. PMID: 27916274 Free article.
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
Mellitzer G, Bonné S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G, Heimberg H. Mellitzer G, et al. Among authors: heimberg h. EMBO J. 2006 Mar 22;25(6):1344-52. doi: 10.1038/sj.emboj.7601011. Epub 2006 Mar 2. EMBO J. 2006. PMID: 16511571 Free PMC article.
Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.
Swales N, Martens GA, Bonné S, Heremans Y, Borup R, Van de Casteele M, Ling Z, Pipeleers D, Ravassard P, Nielsen F, Ferrer J, Heimberg H. Swales N, et al. Among authors: heimberg h. PLoS One. 2012;7(5):e37055. doi: 10.1371/journal.pone.0037055. Epub 2012 May 14. PLoS One. 2012. PMID: 22606327 Free PMC article.
122 results