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Metabolomics in human SGBS cells as new approach method for studying adipogenic effects: Analysis of the effects of DINCH and MINCH on central carbon metabolism.
Goerdeler C, Engelmann B, Aldehoff AS, Schaffert A, Blüher M, Heiker JT, Wabitsch M, Schubert K, Rolle-Kampczyk U, von Bergen M. Goerdeler C, et al. Among authors: heiker jt. Environ Res. 2024 Apr 4;252(Pt 2):118847. doi: 10.1016/j.envres.2024.118847. Online ahead of print. Environ Res. 2024. PMID: 38582427 Free article.
LRP1 is the cell-surface endocytosis receptor for vaspin in adipocytes.
Tindall CA, Möhlis K, Rapöhn I, Dommel S, Riedl V, Schneekönig M, Höfling C, Roßner S, Stichel J, Beck-Sickinger AG, Weiner J, Heiker JT. Tindall CA, et al. Among authors: heiker jt. FEBS J. 2023 Nov 3. doi: 10.1111/febs.16991. Online ahead of print. FEBS J. 2023. PMID: 37921063
Genetic dissection of serum vaspin highlights its causal role in lipid metabolism.
Breitfeld J, Horn K, Le Duc D, Velluva A, Marzi C, Grallert H, Friedrich N, Pietzner M, Völker U, Völzke H, Ahlqvist E, Aly DM, Tuomi T, Baber R, Kratzsch J, Thiery J, Isermann B, Loeffler M, Klöting N, Blüher M, Stumvoll M, Heiker JT, Tönjes A, Scholz M, Kovacs P. Breitfeld J, et al. Among authors: heiker jt. Obesity (Silver Spring). 2023 Nov;31(11):2862-2874. doi: 10.1002/oby.23882. Epub 2023 Sep 26. Obesity (Silver Spring). 2023. PMID: 37752728
Overexpressing high levels of human vaspin limits high fat diet-induced obesity and enhances energy expenditure in a transgenic mouse.
Rapöhn I, Elias I, Weiner J, Pujol A, Kehr S, Chadt A, Al-Hasani H, Burkhardt R, Klöting N, Stumvoll M, Bosch F, Kovacs P, Heiker JT, Breitfeld J. Rapöhn I, et al. Among authors: heiker jt. Front Endocrinol (Lausanne). 2023 Apr 19;14:1146454. doi: 10.3389/fendo.2023.1146454. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37152954 Free PMC article.
Thyroid hormones regulate Zfp423 expression in regionally distinct adipose depots through direct and cell-autonomous action.
Roth L, Johann K, Hönes GS, Oelkrug R, Wagner L, Hoffmann A, Krohn K, Moeller LC, Weiner J, Heiker JT, Klöting N, Tönjes A, Stumvoll M, Blüher M, Mittag J, Krause K. Roth L, et al. Among authors: heiker jt. Cell Rep. 2023 Feb 28;42(2):112088. doi: 10.1016/j.celrep.2023.112088. Epub 2023 Feb 7. Cell Rep. 2023. PMID: 36753417 Free article.
Myoglobin-mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans.
Christen L, Broghammer H, Rapöhn I, Möhlis K, Strehlau C, Ribas-Latre A, Gebhardt C, Roth L, Krause K, Landgraf K, Körner A, Rohde-Zimmermann K, Hoffmann A, Klöting N, Ghosh A, Sun W, Dong H, Wolfrum C, Rassaf T, Hendgen-Cotta UB, Stumvoll M, Blüher M, Heiker JT, Weiner J. Christen L, et al. Among authors: heiker jt. Clin Transl Med. 2022 Dec;12(12):e1108. doi: 10.1002/ctm2.1108. Clin Transl Med. 2022. PMID: 36480426 Free PMC article.
Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity.
Münzker J, Haase N, Till A, Sucher R, Haange SB, Nemetschke L, Gnad T, Jäger E, Chen J, Riede SJ, Chakaroun R, Massier L, Kovacs P, Ost M, Rolle-Kampczyk U, Jehmlich N, Weiner J, Heiker JT, Klöting N, Seeger G, Morawski M, Keitel V, Pfeifer A, von Bergen M, Heeren J, Krügel U, Fenske WK. Münzker J, et al. Among authors: heiker jt. Microbiome. 2022 Jun 24;10(1):96. doi: 10.1186/s40168-022-01264-5. Microbiome. 2022. PMID: 35739571 Free PMC article.
Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic homeostasis in mature adipocytes.
Schaffert A, Karkossa I, Ueberham E, Schlichting R, Walter K, Arnold J, Blüher M, Heiker JT, Lehmann J, Wabitsch M, Escher BI, von Bergen M, Schubert K. Schaffert A, et al. Among authors: heiker jt. Environ Int. 2022 Jun;164:107279. doi: 10.1016/j.envint.2022.107279. Epub 2022 May 6. Environ Int. 2022. PMID: 35567983 Free article.
64 results