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Page 1
In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution.
Fischer A, Lersch R, de Andrade Krätzig N, Strong A, Friedrich MJ, Weber J, Engleitner T, Öllinger R, Yen HY, Kohlhofer U, Gonzalez-Menendez I, Sailer D, Kogan L, Lahnalampi M, Laukkanen S, Kaltenbacher T, Klement C, Rezaei M, Ammon T, Montero JJ, Schneider G, Mayerle J, Heikenwälder M, Schmidt-Supprian M, Quintanilla-Martinez L, Steiger K, Liu P, Cadiñanos J, Vassiliou GS, Saur D, Lohi O, Heinäniemi M, Conte N, Bradley A, Rad L, Rad R. Fischer A, et al. Among authors: heikenwalder m. Cell Genom. 2023 Mar 8;3(3):100276. doi: 10.1016/j.xgen.2023.100276. eCollection 2023 Mar 8. Cell Genom. 2023. PMID: 36950387 Free PMC article.
Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice.
Funk MC, Gleixner JG, Heigwer F, Vonficht D, Valentini E, Aydin Z, Tonin E, Del Prete S, Mahara S, Throm Y, Hetzer J, Heide D, Stegle O, Odom DT, Feldmann A, Haas S, Heikenwalder M, Boutros M. Funk MC, et al. Among authors: heikenwalder m. Dev Cell. 2023 Dec 18;58(24):2914-2929.e7. doi: 10.1016/j.devcel.2023.11.013. Dev Cell. 2023. PMID: 38113852 Free article.
A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1.
Gallage S, Ali A, Barragan Avila JE, Seymen N, Ramadori P, Joerke V, Zizmare L, Aicher D, Gopalsamy IK, Fong W, Kosla J, Focaccia E, Li X, Yousuf S, Sijmonsma T, Rahbari M, Kommoss KS, Billeter A, Prokosch S, Rothermel U, Mueller F, Hetzer J, Heide D, Schinkel B, Machauer T, Pichler B, Malek NP, Longerich T, Roth S, Rose AJ, Schwenck J, Trautwein C, Karimi MM, Heikenwalder M. Gallage S, et al. Among authors: heikenwalder m. Cell Metab. 2024 May 2:S1550-4131(24)00135-9. doi: 10.1016/j.cmet.2024.04.015. Online ahead of print. Cell Metab. 2024. PMID: 38718791 Free article.
Spatially Resolved Multi-Omics Single-Cell Analyses Inform Mechanisms of Immune Dysfunction in Pancreatic Cancer.
Yousuf S, Qiu M, Voith von Voithenberg L, Hulkkonen J, Macinkovic I, Schulz AR, Hartmann D, Mueller F, Mijatovic M, Ibberson D, AlHalabi KT, Hetzer J, Anders S, Brüne B, Mei HE, Imbusch CD, Brors B, Heikenwälder M, Gaida MM, Büchler MW, Weigert A, Hackert T, Roth S. Yousuf S, et al. Among authors: heikenwalder m. Gastroenterology. 2023 Oct;165(4):891-908.e14. doi: 10.1053/j.gastro.2023.05.036. Epub 2023 May 30. Gastroenterology. 2023. PMID: 37263303 Free article.
Corrigendum to "Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation" [J Hepatol (2023) 645-656].
Colasanti O, Burm R, Huang HE, Riedl T, Traut J, Gillich N, Li TF, Corneillie L, Faure-Dupuy S, Grünvogel O, Heide D, Lee JY, Tran CS, Merle U, Chironna M, Vondran FFW, Esser-Nobis K, Binder M, Bartenschlager R, Heikenwälder M, Meuleman P, Lohmann V. Colasanti O, et al. Among authors: heikenwalder m. J Hepatol. 2024 Jan;80(1):171-172. doi: 10.1016/j.jhep.2023.11.007. Epub 2023 Nov 30. J Hepatol. 2024. PMID: 38040570 Free article. No abstract available.
Etiology-independent activation of the LTβ-LTβR-RELB axis drives aggressiveness and predicts poor prognosis in HCC.
Scherr AL, Nader L, Xu K, Elssner C, Ridder DA, Nichetti F, Mastel M, Fritzsche S, Kelmendi E, Schmitt N, Hoffmeister-Wittmann P, Weiler SME, Korell F, Albrecht T, Schwab M, Isele H, Kessler A, Hüllein J, Seretny A, Ye L, Urbanik T, Welte S, Leblond AL, Heilig CE, Rahbari M, Ali A, Gallage S, Lenoir B, Wilhelm N, Gärtner U, Ogrodnik SJ, Springfeld C, Tschaharganeh D, Fröhling S, Longerich T, Schulze-Bergkamen H, Jäger D, Brandl L, Schirmacher P, Straub BK, Weber A, De Toni EN, Goeppert B, Heikenwalder M, Jackstadt R, Roessler S, Breuhahn K, Köhler BC. Scherr AL, et al. Among authors: heikenwalder m. Hepatology. 2023 Nov 2. doi: 10.1097/HEP.0000000000000657. Online ahead of print. Hepatology. 2023. PMID: 37916976
Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes.
Esser K, Cheng X, Wettengel JM, Lucifora J, Hansen-Palmus L, Austen K, Roca Suarez AA, Heintz S, Testoni B, Nebioglu F, Pham MT, Yang S, Zernecke A, Wohlleber D, Ringelhan M, Broxtermann M, Hartmann D, Hüser N, Mergner J, Pichlmair A, Thasler WE, Heikenwalder M, Gasteiger G, Blutke A, Walch A, Knolle PA, Bartenschlager R, Protzer U. Esser K, et al. Among authors: heikenwalder m. Cell Mol Gastroenterol Hepatol. 2023;16(2):201-221. doi: 10.1016/j.jcmgh.2023.03.011. Epub 2023 Apr 11. Cell Mol Gastroenterol Hepatol. 2023. PMID: 37054914 Free PMC article.
Semaphorin 3C exacerbates liver fibrosis.
De Angelis Rigotti F, Wiedmann L, Hubert MO, Vacca M, Hasan SS, Moll I, Carvajal S, Jiménez W, Starostecka M, Billeter AT, Müller-Stich B, Wolff G, Ekim-Üstünel B, Herzig S, Fandos-Ramo C, Krätzner R, Reich M, Keitel-Anselmino V, Heikenwälder M, Mogler C, Fischer A, Rodriguez-Vita J. De Angelis Rigotti F, et al. Among authors: heikenwalder m. Hepatology. 2023 Oct 1;78(4):1092-1105. doi: 10.1097/HEP.0000000000000407. Epub 2023 Apr 15. Hepatology. 2023. PMID: 37055018
327 results