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Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice.
Funk MC, Gleixner JG, Heigwer F, Vonficht D, Valentini E, Aydin Z, Tonin E, Del Prete S, Mahara S, Throm Y, Hetzer J, Heide D, Stegle O, Odom DT, Feldmann A, Haas S, Heikenwalder M, Boutros M. Funk MC, et al. Among authors: heigwer f. Dev Cell. 2023 Dec 18;58(24):2914-2929.e7. doi: 10.1016/j.devcel.2023.11.013. Dev Cell. 2023. PMID: 38113852 Free article.
Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2.
Prasad V, Cerikan B, Stahl Y, Kopp K, Magg V, Acosta-Rivero N, Kim H, Klein K, Funaya C, Haselmann U, Cortese M, Heigwer F, Bageritz J, Bitto D, Jargalsaikhan S, Neufeldt C, Pahmeier F, Boutros M, Yamauchi Y, Ruggieri A, Bartenschlager R. Prasad V, et al. Among authors: heigwer f. Mol Cell. 2023 Jul 20;83(14):2559-2577.e8. doi: 10.1016/j.molcel.2023.06.020. Epub 2023 Jul 7. Mol Cell. 2023. PMID: 37421942 Free article.
A global genetic interaction network by single-cell imaging and machine learning.
Heigwer F, Scheeder C, Bageritz J, Yousefian S, Rauscher B, Laufer C, Beneyto-Calabuig S, Funk MC, Peters V, Boulougouri M, Bilanovic J, Miersch T, Schmitt B, Blass C, Port F, Boutros M. Heigwer F, et al. Cell Syst. 2023 May 17;14(5):346-362.e6. doi: 10.1016/j.cels.2023.03.003. Epub 2023 Apr 27. Cell Syst. 2023. PMID: 37116498 Free PMC article.
Targeting euchromatic histone lysine methyltransferases sensitizes colorectal cancer to histone deacetylase inhibitors.
Bamberg LV, Heigwer F, Wandmacher AM, Singh A, Betge J, Rindtorff N, Werner J, Josten J, Skabkina OV, Hinsenkamp I, Erdmann G, Röcken C, Ebert MP, Burgermeister E, Zhan T, Boutros M. Bamberg LV, et al. Among authors: heigwer f. Int J Cancer. 2022 Nov 1;151(9):1586-1601. doi: 10.1002/ijc.34155. Epub 2022 Jun 28. Int J Cancer. 2022. PMID: 35666536 Free article.
SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB.
Neufeldt CJ, Cerikan B, Cortese M, Frankish J, Lee JY, Plociennikowska A, Heigwer F, Prasad V, Joecks S, Burkart SS, Zander DY, Subramanian B, Gimi R, Padmanabhan S, Iyer R, Gendarme M, El Debs B, Halama N, Merle U, Boutros M, Binder M, Bartenschlager R. Neufeldt CJ, et al. Among authors: heigwer f. Commun Biol. 2022 Jan 12;5(1):45. doi: 10.1038/s42003-021-02983-5. Commun Biol. 2022. PMID: 35022513 Free PMC article.
A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila.
Port F, Strein C, Stricker M, Rauscher B, Heigwer F, Zhou J, Beyersdörffer C, Frei J, Hess A, Kern K, Lange L, Langner N, Malamud R, Pavlović B, Rädecke K, Schmitt L, Voos L, Valentini E, Boutros M. Port F, et al. Among authors: heigwer f. Elife. 2020 Feb 13;9:e53865. doi: 10.7554/eLife.53865. Elife. 2020. PMID: 32053108 Free PMC article.
Machine learning and image-based profiling in drug discovery.
Scheeder C, Heigwer F, Boutros M. Scheeder C, et al. Among authors: heigwer f. Curr Opin Syst Biol. 2018 Aug;10:43-52. doi: 10.1016/j.coisb.2018.05.004. Curr Opin Syst Biol. 2018. PMID: 30159406 Free PMC article. Review.
RNA Interference (RNAi) Screening in Drosophila.
Heigwer F, Port F, Boutros M. Heigwer F, et al. Genetics. 2018 Mar;208(3):853-874. doi: 10.1534/genetics.117.300077. Genetics. 2018. PMID: 29487145 Free PMC article.
22 results