Heidel FH - Search Results

1

Molecular Mechanisms of Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia: Ongoing Challenges and Future Treatments.

Scholl S, Fleischmann M, Schnetzke U, Heidel FH. Scholl S, et al. Among authors: heidel fh. Cells. 2020 Nov 17;9(11):2493. doi: 10.3390/cells9112493. Cells. 2020. PMID: 33212779 Free PMC article. Review.

2

Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain.

Heidel F, Solem FK, Breitenbuecher F, Lipka DB, Kasper S, Thiede MH, Brandts C, Serve H, Roesel J, Giles F, Feldman E, Ehninger G, Schiller GJ, Nimer S, Stone RM, Wang Y, Kindler T, Cohen PS, Huber C, Fischer T. Heidel F, et al. Blood. 2006 Jan 1;107(1):293-300. doi: 10.1182/blood-2005-06-2469. Epub 2005 Sep 8. Blood. 2006. PMID: 16150941 Free article.

3

Ponatinib may overcome resistance of FLT3-ITD harbouring additional point mutations, notably the previously refractory F691I mutation.

Zirm E, Spies-Weisshart B, Heidel F, Schnetzke U, Böhmer FD, Hochhaus A, Fischer T, Scholl S. Zirm E, et al. Br J Haematol. 2012 May;157(4):483-92. doi: 10.1111/j.1365-2141.2012.09085.x. Epub 2012 Mar 13. Br J Haematol. 2012. PMID: 22409268 Free article.

4

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.

Arora D, Köthe S, van den Eijnden M, Hooft van Huijsduijnen R, Heidel F, Fischer T, Scholl S, Tölle B, Böhmer SA, Lennartsson J, Isken F, Müller-Tidow C, Böhmer FD. Arora D, et al. Cell Commun Signal. 2012 Jul 11;10(1):19. doi: 10.1186/1478-811X-10-19. Cell Commun Signal. 2012. PMID: 22784513 Free PMC article.

5

NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells.

Jayavelu AK, Müller JP, Bauer R, Böhmer SA, Lässig J, Cerny-Reiterer S, Sperr WR, Valent P, Maurer B, Moriggl R, Schröder K, Shah AM, Fischer M, Scholl S, Barth J, Oellerich T, Berg T, Serve H, Frey S, Fischer T, Heidel FH, Böhmer FD. Jayavelu AK, et al. Among authors: heidel fh. Leukemia. 2016 Feb;30(2):473-83. doi: 10.1038/leu.2015.234. Epub 2015 Aug 26. Leukemia. 2016. PMID: 26308771

6

Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation.

Tsitsipatis D, Jayavelu AK, Müller JP, Bauer R, Schmidt-Arras D, Mahboobi S, Schnöder TM, Heidel F, Böhmer FD. Tsitsipatis D, et al. Oncotarget. 2017 Apr 18;8(16):26613-26624. doi: 10.18632/oncotarget.15772. Oncotarget. 2017. PMID: 28460451 Free PMC article.

7

Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia.

Kresinsky A, Bauer R, Schnöder TM, Berg T, Meyer D, Ast V, König R, Serve H, Heidel FH, Böhmer FD, Müller JP. Kresinsky A, et al. Among authors: heidel fh. Haematologica. 2018 Nov;103(11):e505-e509. doi: 10.3324/haematol.2017.185306. Epub 2018 Jun 7. Haematologica. 2018. PMID: 29880609 Free PMC article. No abstract available.

8

Epigenetic Erosion in Adult Stem Cells: Drivers and Passengers of Aging.

Kosan C, Heidel FH, Godmann M, Bierhoff H. Kosan C, et al. Among authors: heidel fh. Cells. 2018 Nov 29;7(12):237. doi: 10.3390/cells7120237. Cells. 2018. PMID: 30501028 Free PMC article. Review.

9

Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation.

Perner F, Perner C, Ernst T, Heidel FH. Perner F, et al. Among authors: heidel fh. Cells. 2019 Aug 8;8(8):854. doi: 10.3390/cells8080854. Cells. 2019. PMID: 31398915 Free PMC article. Review.

10

The acetyltransferase GCN5 maintains ATRA-resistance in non-APL AML.

Kahl M, Brioli A, Bens M, Perner F, Kresinsky A, Schnetzke U, Hinze A, Sbirkov Y, Stengel S, Simonetti G, Martinelli G, Petrie K, Zelent A, Böhmer FD, Groth M, Ernst T, Heidel FH, Scholl S, Hochhaus A, Schenk T. Kahl M, et al. Among authors: heidel fh. Leukemia. 2019 Nov;33(11):2628-2639. doi: 10.1038/s41375-019-0581-y. Epub 2019 Oct 1. Leukemia. 2019. PMID: 31576004

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