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Mechanism-based corrector combination restores ΔF508-CFTR folding and function.
Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL. Okiyoneda T, et al. Among authors: hegedus t. Nat Chem Biol. 2013 Jul;9(7):444-54. doi: 10.1038/nchembio.1253. Epub 2013 May 12. Nat Chem Biol. 2013. PMID: 23666117 Free PMC article.
Nanomechanics combined with HDX reveals allosteric drug binding sites of CFTR NBD1.
Padányi R, Farkas B, Tordai H, Kiss B, Grubmüller H, Soya N, Lukács GL, Kellermayer M, Hegedűs T. Padányi R, et al. Among authors: hegedus t. Comput Struct Biotechnol J. 2022 May 23;20:2587-2599. doi: 10.1016/j.csbj.2022.05.036. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35685375 Free PMC article.
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.
Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. Veit G, et al. Among authors: hegedus t. Sci Transl Med. 2014 Jul 23;6(246):246ra97. doi: 10.1126/scitranslmed.3008889. Sci Transl Med. 2014. PMID: 25101887 Free PMC article.
Molecular dynamics of the cryo-EM CFTR structure.
Tordai H, Leveles I, Hegedűs T. Tordai H, et al. Among authors: hegedus t. Biochem Biophys Res Commun. 2017 Sep 30;491(4):986-993. doi: 10.1016/j.bbrc.2017.07.165. Epub 2017 Jul 31. Biochem Biophys Res Commun. 2017. PMID: 28774558
Discovering the chloride pathway in the CFTR channel.
Farkas B, Tordai H, Padányi R, Tordai A, Gera J, Paragi G, Hegedűs T. Farkas B, et al. Among authors: hegedus t. Cell Mol Life Sci. 2020 Feb;77(4):765-778. doi: 10.1007/s00018-019-03211-4. Epub 2019 Jul 20. Cell Mol Life Sci. 2020. PMID: 31327045 Free PMC article.
Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating.
He L, Aleksandrov AA, Serohijos AW, Hegedus T, Aleksandrov LA, Cui L, Dokholyan NV, Riordan JR. He L, et al. Among authors: hegedus t. J Biol Chem. 2008 Sep 26;283(39):26383-90. doi: 10.1074/jbc.M803894200. Epub 2008 Jul 25. J Biol Chem. 2008. PMID: 18658148 Free PMC article.
A recently constructed computational model of the CFTR three-dimensional structure, supported by experimental data (Serohijos, A. W., Hegedus, T., Aleksandrov, A. A., He, L., Cui, L., Dokholyan, N. V., and Riordan, J. ...
A recently constructed computational model of the CFTR three-dimensional structure, supported by experimental data (Serohijos, A. W., Heg …
77 results