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PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Autophagy. 2020 Mar;16(3):466-485. doi: 10.1080/15548627.2019.1628538. Epub 2019 Jun 25.
Autophagy. 2020.
PMID: 31238788
Free PMC article.
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
Thayer JA, Awad O, Hegdekar N, Sarkar C, Tesfay H, Burt C, Zeng X, Feldman RA, Lipinski MM.
Thayer JA, et al. Among authors: hegdekar n.
Autophagy. 2020 Jan;16(1):140-153. doi: 10.1080/15548627.2019.1598754. Epub 2019 Apr 7.
Autophagy. 2020.
PMID: 30957634
Free PMC article.
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N-Acetyl-L-leucine improves functional recovery and attenuates cortical cell death and neuroinflammation after traumatic brain injury in mice.
Hegdekar N, Lipinski MM, Sarkar C.
Hegdekar N, et al.
Sci Rep. 2021 Apr 29;11(1):9249. doi: 10.1038/s41598-021-88693-8.
Sci Rep. 2021.
PMID: 33927281
Free PMC article.
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Structure-specific, accurate quantitation of plasmalogen glycerophosphoethanolamine.
Morel Y, Hegdekar N, Sarkar C, Lipinski MM, Kane MA, Jones JW.
Morel Y, et al. Among authors: hegdekar n.
Anal Chim Acta. 2021 Nov 22;1186:339088. doi: 10.1016/j.aca.2021.339088. Epub 2021 Sep 22.
Anal Chim Acta. 2021.
PMID: 34756256
Free PMC article.
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Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes.
Hegdekar N, Sarkar C, Bustos S, Ritzel RM, Hanscom M, Ravishankar P, Philkana D, Wu J, Loane DJ, Lipinski MM.
Hegdekar N, et al.
Autophagy. 2023 Jul;19(7):2026-2044. doi: 10.1080/15548627.2023.2167689. Epub 2023 Jan 18.
Autophagy. 2023.
PMID: 36652438
Free PMC article.
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