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Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance.
Lan T, Ganapathy US, Sharma S, Ahn YM, Zimmerman M, Molodtsov V, Hegde P, Gengenbacher M, Ebright RH, Dartois V, Freundlich JS, Dick T, Aldrich CC. Lan T, et al. Among authors: hegde p. Angew Chem Int Ed Engl. 2022 Nov 7;61(45):e202211498. doi: 10.1002/anie.202211498. Epub 2022 Oct 12. Angew Chem Int Ed Engl. 2022. PMID: 36222275 Free PMC article.
Mycobacterium tuberculosis PanD Structure-Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor.
Ragunathan P, Cole M, Latka C, Aragaw WW, Hegde P, Shin J, Subramanian Manimekalai MS, Rishikesan S, Aldrich CC, Dick T, Grüber G. Ragunathan P, et al. Among authors: hegde p. ACS Chem Biol. 2021 Jun 18;16(6):1030-1039. doi: 10.1021/acschembio.1c00131. Epub 2021 May 13. ACS Chem Biol. 2021. PMID: 33984234 Free PMC article.
Reinvestigation of the structure-activity relationships of isoniazid.
Hegde P, Boshoff HIM, Rusman Y, Aragaw WW, Salomon CE, Dick T, Aldrich CC. Hegde P, et al. Tuberculosis (Edinb). 2021 Jul;129:102100. doi: 10.1016/j.tube.2021.102100. Epub 2021 Jun 5. Tuberculosis (Edinb). 2021. PMID: 34116482 Free PMC article.
Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria.
Schultz JR, Costa SK, Jachak GR, Hegde P, Zimmerman M, Pan Y, Josten M, Ejeh C, Hammerstad T, Sahl HG, Pereira PM, Pinho MG, Dartois V, Cheung A, Aldrich CC. Schultz JR, et al. Among authors: hegde p. J Med Chem. 2022 Oct 27;65(20):13910-13934. doi: 10.1021/acs.jmedchem.2c01151. Epub 2022 Oct 11. J Med Chem. 2022. PMID: 36219779 Free PMC article.
404 results