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Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 Mice.
Viruses. 2021 Aug 20;13(8):1656. doi: 10.3390/v13081656.
Viruses. 2021.
PMID: 34452519
Free PMC article.
Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro.
Paull JRA, Heery GP, Bobardt MD, Castellarnau A, Luscombe CA, Fairley JK, Gallay PA.
Paull JRA, et al. Among authors: heery gp.
Antiviral Res. 2021 Jul;191:105089. doi: 10.1016/j.antiviral.2021.105089. Epub 2021 May 16.
Antiviral Res. 2021.
PMID: 34010661
Free PMC article.
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Topical Astodrimer Sodium, a Non-Toxic Polyanionic Dendrimer, Demonstrates Antiviral Activity in an Experimental Ocular Adenovirus Infection Model.
Romanowski EG, Yates KA, Paull JRA, Heery GP, Shanks RMQ.
Romanowski EG, et al. Among authors: heery gp.
Molecules. 2021 Jun 5;26(11):3419. doi: 10.3390/molecules26113419.
Molecules. 2021.
PMID: 34198721
Free PMC article.
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Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial.
Castellarnau A, Heery GP, Seta A, Luscombe CA, Kinghorn GR, Button P, McCloud P, Paull JRA.
Castellarnau A, et al. Among authors: heery gp.
Sci Rep. 2022 Jun 17;12(1):10210. doi: 10.1038/s41598-022-14601-3.
Sci Rep. 2022.
PMID: 35715644
Free PMC article.
Clinical Trial.
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Dendrimers as drugs: discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention.
McCarthy TD, Karellas P, Henderson SA, Giannis M, O'Keefe DF, Heery G, Paull JR, Matthews BR, Holan G.
McCarthy TD, et al.
Mol Pharm. 2005 Jul-Aug;2(4):312-8. doi: 10.1021/mp050023q.
Mol Pharm. 2005.
PMID: 16053334
Review.
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