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The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity.
Stewart H, Lu Y, O'Keefe S, Valpadashi A, Cruz-Zaragoza LD, Michel HA, Nguyen SK, Carnell GW, Lukhovitskaya N, Milligan R, Adewusi Y, Jungreis I, Lulla V, Matthews DA, High S, Rehling P, Emmott E, Heeney JL, Davidson AD, Edgar JR, Smith GL, Firth AE. Stewart H, et al. Among authors: heeney jl. iScience. 2023 Sep 28;26(11):108080. doi: 10.1016/j.isci.2023.108080. eCollection 2023 Nov 17. iScience. 2023. PMID: 37860693 Free PMC article.
Vaccination and protective immunity to SARS-CoV-2 omicron variants in people with immunodeficiencies.
Nadesalingam A, Cantoni D, Aguinam ET, Chan AC, Paloniemi M, Ohlendorf L, George C, Carnell G, Lyall J, Ferrari M, Temperton N, Wagner R, Castillo-Olivares J, Baxendale H, Heeney JL. Nadesalingam A, et al. Among authors: heeney jl. Lancet Microbe. 2023 Feb;4(2):e58-e59. doi: 10.1016/S2666-5247(22)00297-X. Epub 2022 Nov 1. Lancet Microbe. 2023. PMID: 36332646 Free PMC article. No abstract available.
Immunogenicity of a silica nanoparticle-based SARS-CoV-2 vaccine in mice.
Barbey C, Su J, Billmeier M, Stefan N, Bester R, Carnell G, Temperton N, Heeney J, Protzer U, Breunig M, Wagner R, Peterhoff D. Barbey C, et al. Eur J Pharm Biopharm. 2023 Nov;192:41-55. doi: 10.1016/j.ejpb.2023.09.015. Epub 2023 Sep 27. Eur J Pharm Biopharm. 2023. PMID: 37774890 Free article.
Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release.
Stewart H, Palmulli R, Johansen KH, McGovern N, Shehata OM, Carnell GW, Jackson HK, Lee JS, Brown JC, Burgoyne T, Heeney JL, Okkenhaug K, Firth AE, Peden AA, Edgar JR. Stewart H, et al. Among authors: heeney jl. EMBO Rep. 2023 Dec 6;24(12):e57224. doi: 10.15252/embr.202357224. Epub 2023 Oct 11. EMBO Rep. 2023. PMID: 37818801 Free PMC article.
Inhibition of the Lectin Pathway of Complement Activation Reduces Acute Respiratory Distress Syndrome Severity in a Mouse Model of SARS-CoV-2 Infection.
Ali YM, Carnell GW, Fumagalli S, Mercurio D, Seminara S, Lynch NJ, Khatri P, Arachchilage CH, Mascheroni L, Kaminski C, George CL, Stewart H, Yabuki M, Demopulos G, Heeney JL, Schwaeble W. Ali YM, et al. Among authors: heeney jl. J Infect Dis. 2024 Mar 14;229(3):680-690. doi: 10.1093/infdis/jiad462. J Infect Dis. 2024. PMID: 37878754 Free PMC article.
Glycan masking of a non-neutralising epitope enhances neutralising antibodies targeting the RBD of SARS-CoV-2 and its variants.
Carnell GW, Billmeier M, Vishwanath S, Suau Sans M, Wein H, George CL, Neckermann P, Del Rosario JMM, Sampson AT, Einhauser S, Aguinam ET, Ferrari M, Tonks P, Nadesalingam A, Schütz A, Huang CQ, Wells DA, Paloniemi M, Jordan I, Cantoni D, Peterhoff D, Asbach B, Sandig V, Temperton N, Kinsley R, Wagner R, Heeney JL. Carnell GW, et al. Among authors: heeney jl. Front Immunol. 2023 Feb 23;14:1118523. doi: 10.3389/fimmu.2023.1118523. eCollection 2023. Front Immunol. 2023. PMID: 36911730 Free PMC article.
Differential T-cell and antibody responses induced by mRNA versus adenoviral vectored COVID-19 vaccines in patients with immunodeficiencies.
Aguinam ET, Nadesalingam A, Chan A, Smith P, Paloniemi M, Cantoni D, Gronlund J, Gronlund H, Carnell GW, Castillo-Olivares J, Temperton N, Blacklaws B, Heeney JL, Baxendale H. Aguinam ET, et al. Among authors: heeney jl. J Allergy Clin Immunol Glob. 2023 May;2(2):100091. doi: 10.1016/j.jacig.2023.100091. Epub 2023 Mar 15. J Allergy Clin Immunol Glob. 2023. PMID: 37038555 Free PMC article.
Immunological insights into COVID-19 in Southern Nigeria.
Ugwu CA, Alao O, John OG, Akinnawo B, Ajayi I, Odebode O, Bejide I, Campbell A, Campbell J, Adole JA, B Olawoye I, Akano K, Okolie J, Eromon P, Olaitan P, Olagunoye A, Adebayo I, Adebayo V, Babalola E, Abioye O, Ajayi N, Ogah E, Ukwaja K, Okoro S, Oje O, Kingsley OC, Eke M, Onyia V, Achonduh-Atijegbe O, Ewah FE, Obasi M, Igwe V, Ayodeji O, Chukwuyem A, Owhin S, Oyejide N, Abah S, Ingbian W, Osoba M, Alebiosu A, Nadesalingam A, Aguinam ET, Carnell G, Krause N, Chan A, George C, Kinsley R, Tonks P, Temperton N, Heeney J, Happi C. Ugwu CA, et al. Front Immunol. 2024 Jan 23;15:1305586. doi: 10.3389/fimmu.2024.1305586. eCollection 2024. Front Immunol. 2024. PMID: 38322252 Free PMC article.
Humoral and cellular immune responses to Lassa fever virus in Lassa fever survivors and their exposed contacts in Southern Nigeria.
Ugwu C, Olumade T, Nwakpakpa E, Onyia V, Odeh E, Duruiheoma RO, Ojide CK, Eke MA, Nwafor IE, Chika-Igwenyi N, Abu AM, Azuogu B, Ajayi N, Ogah E, Ayodeji O, Abejegah C, Adedosu N, Oyejide N, Abah S, Omidele A, Ingbian W, Osoba E, Eromon P, Oluniyi P, Ogunsanya O, Happi A, Otuh P, Nadesalingam A, Carnell G, Krause N, Aguinam E, Kinsley R, Storisteanu DML, Tonks P, Nelson D, McAlister C, Boisen M, Garry R, Wright E, Temperton N, Frost S, Heeney JL, Happi C. Ugwu C, et al. Among authors: heeney jl. Sci Rep. 2022 Dec 25;12(1):22330. doi: 10.1038/s41598-022-26045-w. Sci Rep. 2022. PMID: 36567369 Free PMC article.
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination.
Liew F, Talwar S, Cross A, Willett BJ, Scott S, Logan N, Siggins MK, Swieboda D, Sidhu JK, Efstathiou C, Moore SC, Davis C, Mohamed N, Nunag J, King C, Thompson AAR, Rowland-Jones SL, Docherty AB, Chalmers JD, Ho LP, Horsley A, Raman B, Poinasamy K, Marks M, Kon OM, Howard L, Wootton DG, Dunachie S, Quint JK, Evans RA, Wain LV, Fontanella S, de Silva TI, Ho A, Harrison E, Baillie JK, Semple MG, Brightling C, Thwaites RS, Turtle L, Openshaw PJM; ISARIC4C Investigators; PHOSP-COVID collaborative group. Liew F, et al. EBioMedicine. 2023 Jan;87:104402. doi: 10.1016/j.ebiom.2022.104402. Epub 2022 Dec 19. EBioMedicine. 2023. PMID: 36543718 Free PMC article.
242 results