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Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers.
Döge N, Hönzke S, Schumacher F, Balzus B, Colombo M, Hadam S, Rancan F, Blume-Peytavi U, Schäfer-Korting M, Schindler A, Rühl E, Skov PS, Church MK, Hedtrich S, Kleuser B, Bodmeier R, Vogt A. Döge N, et al. Among authors: hedtrich s. J Control Release. 2016 Nov 28;242:25-34. doi: 10.1016/j.jconrel.2016.07.009. Epub 2016 Jul 6. J Control Release. 2016. PMID: 27394682
Core-multishell nanocarriers: Transport and release of dexamethasone probed by soft X-ray spectromicroscopy.
Yamamoto K, Klossek A, Flesch R, Ohigashi T, Fleige E, Rancan F, Frombach J, Vogt A, Blume-Peytavi U, Schrade P, Bachmann S, Haag R, Hedtrich S, Schäfer-Korting M, Kosugi N, Rühl E. Yamamoto K, et al. Among authors: hedtrich s. J Control Release. 2016 Nov 28;242:64-70. doi: 10.1016/j.jconrel.2016.08.028. Epub 2016 Aug 24. J Control Release. 2016. PMID: 27568290
Influence of the skin barrier on the penetration of topically-applied dexamethasone probed by soft X-ray spectromicroscopy.
Yamamoto K, Klossek A, Flesch R, Rancan F, Weigand M, Bykova I, Bechtel M, Ahlberg S, Vogt A, Blume-Peytavi U, Schrade P, Bachmann S, Hedtrich S, Schäfer-Korting M, Rühl E. Yamamoto K, et al. Among authors: hedtrich s. Eur J Pharm Biopharm. 2017 Sep;118:30-37. doi: 10.1016/j.ejpb.2016.12.005. Epub 2016 Dec 18. Eur J Pharm Biopharm. 2017. PMID: 27998691
Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery.
Müller F, Hönzke S, Luthardt WO, Wong EL, Unbehauen M, Bauer J, Haag R, Hedtrich S, Rühl E, Rademann J. Müller F, et al. Among authors: hedtrich s. Eur J Pharm Biopharm. 2017 Jul;116:31-37. doi: 10.1016/j.ejpb.2016.12.013. Epub 2016 Dec 21. Eur J Pharm Biopharm. 2017. PMID: 28012989
Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes.
Gerecke C, Edlich A, Giulbudagian M, Schumacher F, Zhang N, Said A, Yealland G, Lohan SB, Neumann F, Meinke MC, Ma N, Calderón M, Hedtrich S, Schäfer-Korting M, Kleuser B. Gerecke C, et al. Among authors: hedtrich s. Nanotoxicology. 2017 Mar;11(2):267-277. doi: 10.1080/17435390.2017.1292371. Epub 2017 Feb 22. Nanotoxicology. 2017. PMID: 28165853
Data-based modeling of drug penetration relates human skin barrier function to the interplay of diffusivity and free-energy profiles.
Schulz R, Yamamoto K, Klossek A, Flesch R, Hönzke S, Rancan F, Vogt A, Blume-Peytavi U, Hedtrich S, Schäfer-Korting M, Rühl E, Netz RR. Schulz R, et al. Among authors: hedtrich s. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3631-3636. doi: 10.1073/pnas.1620636114. Epub 2017 Mar 20. Proc Natl Acad Sci U S A. 2017. PMID: 28320932 Free PMC article.
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