Drug selectivity is determined by coupling across the NAD+ site of IMP dehydrogenase.
Digits JA, Hedstrom L.
Digits JA, et al. Among authors: hedstrom l.
Biochemistry. 2000 Feb 22;39(7):1771-7. doi: 10.1021/bi992288e.
Biochemistry. 2000.
PMID: 10677226
Previous results indicated that about half of the difference in sensitivity derives from residues in the MPA-binding site [Digits, J. A., and Hedstrom, L. (1999) Biochemistry 38, 15388-15397]. The remainder must be attributed to regions outside the MPA-binding site. …
Previous results indicated that about half of the difference in sensitivity derives from residues in the MPA-binding site [Digits, J. A., an …