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Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.
PLoS Biol. 2021 Apr 22;19(4):e3001191. doi: 10.1371/journal.pbio.3001191. eCollection 2021 Apr.
PLoS Biol. 2021.
PMID: 33886552
Free PMC article.
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.
Happ JT, Arveseth CD, Bruystens J, Bertinetti D, Nelson IB, Olivieri C, Zhang J, Hedeen DS, Zhu JF, Capener JL, Bröckel JW, Vu L, King CC, Ruiz-Perez VL, Ge X, Veglia G, Herberg FW, Taylor SS, Myers BR.
Happ JT, et al. Among authors: hedeen ds.
Nat Struct Mol Biol. 2022 Oct;29(10):990-999. doi: 10.1038/s41594-022-00838-z. Epub 2022 Oct 6.
Nat Struct Mol Biol. 2022.
PMID: 36202993
Free PMC article.
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Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.
Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A.
Deshpande I, et al.
Nature. 2019 Jul;571(7764):284-288. doi: 10.1038/s41586-019-1355-4. Epub 2019 Jul 1.
Nature. 2019.
PMID: 31263273
Free PMC article.
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KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion.
Fadul J, Zulueta-Coarasa T, Slattum GM, Redd NM, Jin MF, Redd MJ, Daetwyler S, Hedeen D, Huisken J, Rosenblatt J.
Fadul J, et al.
Nat Commun. 2021 Dec 10;12(1):7180. doi: 10.1038/s41467-021-27513-z.
Nat Commun. 2021.
PMID: 34893591
Free PMC article.
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HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1β.
Tawara K, Scott H, Emathinger J, Wolf C, LaJoie D, Hedeen D, Bond L, Montgomery P, Jorcyk C.
Tawara K, et al.
Oncotarget. 2019 Mar 12;10(21):2068-2085. doi: 10.18632/oncotarget.26699. eCollection 2019 Mar 12.
Oncotarget. 2019.
PMID: 31007849
Free PMC article.
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Co-Expression of VEGF and IL-6 Family Cytokines is Associated with Decreased Survival in HER2 Negative Breast Cancer Patients: Subtype-Specific IL-6 Family Cytokine-Mediated VEGF Secretion.
Tawara K, Scott H, Emathinger J, Ide A, Fox R, Greiner D, LaJoie D, Hedeen D, Nandakumar M, Oler AJ, Holzer R, Jorcyk C.
Tawara K, et al.
Transl Oncol. 2019 Feb;12(2):245-255. doi: 10.1016/j.tranon.2018.10.004. Epub 2018 Nov 12.
Transl Oncol. 2019.
PMID: 30439625
Free PMC article.
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The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation.
Goyden J, Tawara K, Hedeen D, Willey JS, Oxford JT, Jorcyk CL.
Goyden J, et al.
PLoS One. 2015 Jun 1;10(6):e0127230. doi: 10.1371/journal.pone.0127230. eCollection 2015.
PLoS One. 2015.
PMID: 26030441
Free PMC article.
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