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The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.
Sakae DY, Marti F, Lecca S, Vorspan F, Martín-García E, Morel LJ, Henrion A, Gutiérrez-Cuesta J, Besnard A, Heck N, Herzog E, Bolte S, Prado VF, Prado MA, Bellivier F, Eap CB, Crettol S, Vanhoutte P, Caboche J, Gratton A, Moquin L, Giros B, Maldonado R, Daumas S, Mameli M, Jamain S, El Mestikawy S. Sakae DY, et al. Among authors: heck n. Mol Psychiatry. 2015 Nov;20(11):1448-59. doi: 10.1038/mp.2015.104. Epub 2015 Aug 4. Mol Psychiatry. 2015. PMID: 26239290
Rapid Synaptogenesis in the Nucleus Accumbens Is Induced by a Single Cocaine Administration and Stabilized by Mitogen-Activated Protein Kinase Interacting Kinase-1 Activity.
Dos Santos M, Salery M, Forget B, Garcia Perez MA, Betuing S, Boudier T, Vanhoutte P, Caboche J, Heck N. Dos Santos M, et al. Among authors: heck n. Biol Psychiatry. 2017 Dec 1;82(11):806-818. doi: 10.1016/j.biopsych.2017.03.014. Epub 2017 Mar 29. Biol Psychiatry. 2017. PMID: 28545678 Free article.
Cocaine increases dopaminergic connectivity in the nucleus accumbens.
Dos Santos M, Cahill EN, Bo GD, Vanhoutte P, Caboche J, Giros B, Heck N. Dos Santos M, et al. Among authors: heck n. Brain Struct Funct. 2018 Mar;223(2):913-923. doi: 10.1007/s00429-017-1532-x. Epub 2017 Oct 12. Brain Struct Funct. 2018. PMID: 29027032
72 results