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Phosphoproteomics Profiling Defines a Target Landscape of the Basophilic Protein Kinases AKT, S6K, and RSK in Skeletal Myotubes.
Fricke AL, Mühlhäuser WWD, Reimann L, Zimmermann JP, Reichenbach C, Knapp B, Peikert CD, Heberle AM, Faessler E, Schäuble S, Hahn U, Thedieck K, Radziwill G, Warscheid B. Fricke AL, et al. Among authors: heberle am. J Proteome Res. 2023 Mar 3;22(3):768-789. doi: 10.1021/acs.jproteome.2c00505. Epub 2023 Feb 10. J Proteome Res. 2023. PMID: 36763541
A systems study reveals concurrent activation of AMPK and mTOR by amino acids.
Dalle Pezze P, Ruf S, Sonntag AG, Langelaar-Makkinje M, Hall P, Heberle AM, Razquin Navas P, van Eunen K, Tölle RC, Schwarz JJ, Wiese H, Warscheid B, Deitersen J, Stork B, Fäßler E, Schäuble S, Hahn U, Horvatovich P, Shanley DP, Thedieck K. Dalle Pezze P, et al. Among authors: heberle am. Nat Commun. 2016 Nov 21;7:13254. doi: 10.1038/ncomms13254. Nat Commun. 2016. PMID: 27869123 Free PMC article.
The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner.
Heberle AM, Razquin Navas P, Langelaar-Makkinje M, Kasack K, Sadik A, Faessler E, Hahn U, Marx-Stoelting P, Opitz CA, Sers C, Heiland I, Schäuble S, Thedieck K. Heberle AM, et al. Life Sci Alliance. 2019 Mar 28;2(2):e201800257. doi: 10.26508/lsa.201800257. Print 2019 Apr. Life Sci Alliance. 2019. PMID: 30923191 Free PMC article.
Finding new edges: systems approaches to MTOR signaling.
Heberle AM, Rehbein U, Rodríguez Peiris M, Thedieck K. Heberle AM, et al. Biochem Soc Trans. 2021 Feb 26;49(1):41-54. doi: 10.1042/BST20190730. Biochem Soc Trans. 2021. PMID: 33544134 Free PMC article. Review.
mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases.
Cadena Sandoval M, Heberle AM, Rehbein U, Barile C, Ramos Pittol JM, Thedieck K. Cadena Sandoval M, et al. Among authors: heberle am. Front Aging. 2021 Oct 13;2:761333. doi: 10.3389/fragi.2021.761333. eCollection 2021. Front Aging. 2021. PMID: 35822040 Free PMC article. Review.
Cardiac PI3K p110α attenuation delays aging and extends lifespan.
Abdellatif M, Eisenberg T, Heberle AM, Thedieck K, Kroemer G, Sedej S. Abdellatif M, et al. Among authors: heberle am. Cell Stress. 2022 Aug 8;6(8):72-75. doi: 10.15698/cst2022.08.270. eCollection 2022 Aug. Cell Stress. 2022. PMID: 36447531 Free PMC article.
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy.
Ruf S, Heberle AM, Langelaar-Makkinje M, Gelino S, Wilkinson D, Gerbeth C, Schwarz JJ, Holzwarth B, Warscheid B, Meisinger C, van Vugt MA, Baumeister R, Hansen M, Thedieck K. Ruf S, et al. Among authors: heberle am. Autophagy. 2017 Mar 4;13(3):486-505. doi: 10.1080/15548627.2016.1263781. Epub 2017 Jan 19. Autophagy. 2017. PMID: 28102733 Free PMC article.
Comparative Assessment of Quantification Methods for Tumor Tissue Phosphoproteomics.
Zhang Y, Dreyer B, Govorukhina N, Heberle AM, Končarević S, Krisp C, Opitz CA, Pfänder P, Bischoff R, Schlüter H, Kwiatkowski M, Thedieck K, Horvatovich PL. Zhang Y, et al. Among authors: heberle am. Anal Chem. 2022 Aug 9;94(31):10893-10906. doi: 10.1021/acs.analchem.2c01036. Epub 2022 Jul 26. Anal Chem. 2022. PMID: 35880733 Free PMC article.
Tomatidine, a novel antiviral compound towards dengue virus.
Diosa-Toro M, Troost B, van de Pol D, Heberle AM, Urcuqui-Inchima S, Thedieck K, Smit JM. Diosa-Toro M, et al. Among authors: heberle am. Antiviral Res. 2019 Jan;161:90-99. doi: 10.1016/j.antiviral.2018.11.011. Epub 2018 Nov 22. Antiviral Res. 2019. PMID: 30468746 Free article.
16 results