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The SZT2 Interactome Unravels New Functions of the KICSTOR Complex.
Cattelani C, Lesiak D, Liebscher G, Singer II, Stasyk T, Wallnöfer MH, Heberle AM, Corti C, Hess MW, Pfaller K, Kwiatkowski M, Pramstaller PP, Hicks AA, Thedieck K, Müller T, Huber LA, Eca Guimaraes de Araujo M. Cattelani C, et al. Among authors: heberle am. Cells. 2021 Oct 9;10(10):2711. doi: 10.3390/cells10102711. Cells. 2021. PMID: 34685691 Free PMC article.
Molecular mechanisms of mTOR regulation by stress.
Heberle AM, Prentzell MT, van Eunen K, Bakker BM, Grellscheid SN, Thedieck K. Heberle AM, et al. Mol Cell Oncol. 2014 Dec 3;2(2):e970489. doi: 10.4161/23723548.2014.970489. eCollection 2015 Apr-Jun. Mol Cell Oncol. 2014. PMID: 27308421 Free PMC article. Review.
A systems study reveals concurrent activation of AMPK and mTOR by amino acids.
Dalle Pezze P, Ruf S, Sonntag AG, Langelaar-Makkinje M, Hall P, Heberle AM, Razquin Navas P, van Eunen K, Tölle RC, Schwarz JJ, Wiese H, Warscheid B, Deitersen J, Stork B, Fäßler E, Schäuble S, Hahn U, Horvatovich P, Shanley DP, Thedieck K. Dalle Pezze P, et al. Among authors: heberle am. Nat Commun. 2016 Nov 21;7:13254. doi: 10.1038/ncomms13254. Nat Commun. 2016. PMID: 27869123 Free PMC article.
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy.
Ruf S, Heberle AM, Langelaar-Makkinje M, Gelino S, Wilkinson D, Gerbeth C, Schwarz JJ, Holzwarth B, Warscheid B, Meisinger C, van Vugt MA, Baumeister R, Hansen M, Thedieck K. Ruf S, et al. Among authors: heberle am. Autophagy. 2017 Mar 4;13(3):486-505. doi: 10.1080/15548627.2016.1263781. Epub 2017 Jan 19. Autophagy. 2017. PMID: 28102733 Free PMC article.
Tomatidine, a novel antiviral compound towards dengue virus.
Diosa-Toro M, Troost B, van de Pol D, Heberle AM, Urcuqui-Inchima S, Thedieck K, Smit JM. Diosa-Toro M, et al. Among authors: heberle am. Antiviral Res. 2019 Jan;161:90-99. doi: 10.1016/j.antiviral.2018.11.011. Epub 2018 Nov 22. Antiviral Res. 2019. PMID: 30468746 Free article.
The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner.
Heberle AM, Razquin Navas P, Langelaar-Makkinje M, Kasack K, Sadik A, Faessler E, Hahn U, Marx-Stoelting P, Opitz CA, Sers C, Heiland I, Schäuble S, Thedieck K. Heberle AM, et al. Life Sci Alliance. 2019 Mar 28;2(2):e201800257. doi: 10.26508/lsa.201800257. Print 2019 Apr. Life Sci Alliance. 2019. PMID: 30923191 Free PMC article.
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G; Genomics England Research Consortium; de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Prentzell MT, et al. Among authors: heberle am. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. Cell. 2021. PMID: 33497611 Free PMC article.
Finding new edges: systems approaches to MTOR signaling.
Heberle AM, Rehbein U, Rodríguez Peiris M, Thedieck K. Heberle AM, et al. Biochem Soc Trans. 2021 Feb 26;49(1):41-54. doi: 10.1042/BST20190730. Biochem Soc Trans. 2021. PMID: 33544134 Free PMC article. Review.
The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back.
Rehbein U, Prentzell MT, Cadena Sandoval M, Heberle AM, Henske EP, Opitz CA, Thedieck K. Rehbein U, et al. Among authors: heberle am. Front Cell Dev Biol. 2021 Oct 29;9:751892. doi: 10.3389/fcell.2021.751892. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34778262 Free PMC article. Review.
16 results