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Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors.
Schmidt J, Chiffelle J, Perez MAS, Magnin M, Bobisse S, Arnaud M, Genolet R, Cesbron J, Barras D, Navarro Rodrigo B, Benedetti F, Michel A, Queiroz L, Baumgaertner P, Guillaume P, Hebeisen M, Michielin O, Nguyen-Ngoc T, Huber F, Irving M, Tissot-Renaud S, Stevenson BJ, Rusakiewicz S, Dangaj Laniti D, Bassani-Sternberg M, Rufer N, Gfeller D, Kandalaft LE, Speiser DE, Zoete V, Coukos G, Harari A. Schmidt J, et al. Among authors: hebeisen m. Nat Commun. 2023 Jun 6;14(1):3188. doi: 10.1038/s41467-023-38946-z. Nat Commun. 2023. PMID: 37280206 Free PMC article.
Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.
Schmid DA, Irving MB, Posevitz V, Hebeisen M, Posevitz-Fejfar A, Sarria JC, Gomez-Eerland R, Thome M, Schumacher TN, Romero P, Speiser DE, Zoete V, Michielin O, Rufer N. Schmid DA, et al. Among authors: hebeisen m. J Immunol. 2010 May 1;184(9):4936-46. doi: 10.4049/jimmunol.1000173. Epub 2010 Mar 29. J Immunol. 2010. PMID: 20351194
Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness.
Irving M, Zoete V, Hebeisen M, Schmid D, Baumgartner P, Guillaume P, Romero P, Speiser D, Luescher I, Rufer N, Michielin O. Irving M, et al. Among authors: hebeisen m. J Biol Chem. 2012 Jun 29;287(27):23068-78. doi: 10.1074/jbc.M112.357673. Epub 2012 May 1. J Biol Chem. 2012. PMID: 22549784 Free PMC article.
MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.
Dudda JC, Salaun B, Ji Y, Palmer DC, Monnot GC, Merck E, Boudousquie C, Utzschneider DT, Escobar TM, Perret R, Muljo SA, Hebeisen M, Rufer N, Zehn D, Donda A, Restifo NP, Held W, Gattinoni L, Romero P. Dudda JC, et al. Among authors: hebeisen m. Immunity. 2013 Apr 18;38(4):742-53. doi: 10.1016/j.immuni.2012.12.006. Immunity. 2013. PMID: 23601686 Free PMC article.
Heterogeneity assessment of functional T cell avidity.
Ioannidou K, Baumgaertner P, Gannon PO, Speiser MF, Allard M, Hebeisen M, Rufer N, Speiser DE. Ioannidou K, et al. Among authors: hebeisen m. Sci Rep. 2017 Mar 13;7:44320. doi: 10.1038/srep44320. Sci Rep. 2017. PMID: 28287160 Free PMC article.
44 results