Hebditch M - Search Results

1

Modelling of pH-dependence to develop a strategy for stabilising mAbs at acidic steps in production.

Hebditch M, Kean R, Warwicker J. Hebditch M, et al. Comput Struct Biotechnol J. 2020 Mar 10;18:897-905. doi: 10.1016/j.csbj.2020.03.002. eCollection 2020. Comput Struct Biotechnol J. 2020. PMID: 32322371 Free PMC article. Review.

2

Sequence composition predicts immunoglobulin superfamily members that could share the intrinsically disordered properties of antibody CH1 domains.

Hebditch M, Curtis R, Warwicker J. Hebditch M, et al. Sci Rep. 2017 Sep 29;7(1):12404. doi: 10.1038/s41598-017-12616-9. Sci Rep. 2017. PMID: 28963509 Free PMC article.

3

Web-based display of protein surface and pH-dependent properties for assessing the developability of biotherapeutics.

Hebditch M, Warwicker J. Hebditch M, et al. Sci Rep. 2019 Feb 13;9(1):1969. doi: 10.1038/s41598-018-36950-8. Sci Rep. 2019. PMID: 30760735 Free PMC article.

4

Protein-sol pKa: prediction of electrostatic frustration, with application to coronaviruses.

Hebditch M, Warwicker J. Hebditch M, et al. Bioinformatics. 2020 Dec 22;36(20):5112-5114. doi: 10.1093/bioinformatics/btaa646. Bioinformatics. 2020. PMID: 32683439 Free PMC article.

5

Protein-Sol: a web tool for predicting protein solubility from sequence.

Hebditch M, Carballo-Amador MA, Charonis S, Curtis R, Warwicker J. Hebditch M, et al. Bioinformatics. 2017 Oct 1;33(19):3098-3100. doi: 10.1093/bioinformatics/btx345. Bioinformatics. 2017. PMID: 28575391 Free PMC article.

6

Models for Antibody Behavior in Hydrophobic Interaction Chromatography and in Self-Association.

Hebditch M, Roche A, Curtis RA, Warwicker J. Hebditch M, et al. J Pharm Sci. 2019 Apr;108(4):1434-1441. doi: 10.1016/j.xphs.2018.11.035. Epub 2018 Nov 23. J Pharm Sci. 2019. PMID: 30476509

7

Charge and hydrophobicity are key features in sequence-trained machine learning models for predicting the biophysical properties of clinical-stage antibodies.

Hebditch M, Warwicker J. Hebditch M, et al. PeerJ. 2019 Dec 18;7:e8199. doi: 10.7717/peerj.8199. eCollection 2019. PeerJ. 2019. PMID: 31976163 Free PMC article.

8

PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions.

Nicolaou ST, Hebditch M, Jonathan OJ, Verma CS, Warwicker J. Nicolaou ST, et al. Among authors: hebditch m. Sci Rep. 2021 May 11;11(1):9930. doi: 10.1038/s41598-021-88992-0. Sci Rep. 2021. PMID: 33976270 Free PMC article.

9

Self-Interaction of Human Serum Albumin: A Formulation Perspective.

Sønderby P, Bukrinski JT, Hebditch M, Peters GHJ, Curtis RA, Harris P. Sønderby P, et al. Among authors: hebditch m. ACS Omega. 2018 Nov 30;3(11):16105-16117. doi: 10.1021/acsomega.8b02245. Epub 2018 Nov 28. ACS Omega. 2018. PMID: 30556026 Free PMC article.

10

Coarse-Grained Modeling of Antibodies from Small-Angle Scattering Profiles.

Corbett D, Hebditch M, Keeling R, Ke P, Ekizoglou S, Sarangapani P, Pathak J, Van Der Walle CF, Uddin S, Baldock C, Avendaño C, Curtis RA. Corbett D, et al. Among authors: hebditch m. J Phys Chem B. 2017 Sep 7;121(35):8276-8290. doi: 10.1021/acs.jpcb.7b04621. Epub 2017 Aug 25. J Phys Chem B. 2017. PMID: 28796519

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