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Metabolism, hypoxia and the diabetic heart.
Heather LC, Clarke K. Heather LC, et al. J Mol Cell Cardiol. 2011 Apr;50(4):598-605. doi: 10.1016/j.yjmcc.2011.01.007. Epub 2011 Jan 22. J Mol Cell Cardiol. 2011. PMID: 21262230 Review.
Normobaric hypoxia impairs human cardiac energetics.
Holloway C, Cochlin L, Codreanu I, Bloch E, Fatemian M, Szmigielski C, Atherton H, Heather L, Francis J, Neubauer S, Robbins P, Montgomery H, Clarke K. Holloway C, et al. FASEB J. 2011 Sep;25(9):3130-5. doi: 10.1096/fj.11-183426. Epub 2011 Jun 6. FASEB J. 2011. PMID: 21646398
Metabolic adaptation to chronic hypoxia in cardiac mitochondria.
Heather LC, Cole MA, Tan JJ, Ambrose LJ, Pope S, Abd-Jamil AH, Carter EE, Dodd MS, Yeoh KK, Schofield CJ, Clarke K. Heather LC, et al. Basic Res Cardiol. 2012 May;107(3):268. doi: 10.1007/s00395-012-0268-2. Epub 2012 Apr 27. Basic Res Cardiol. 2012. PMID: 22538979
Investigating mitochondrial metabolism in contracting HL-1 cardiomyocytes following hypoxia and pharmacological HIF activation identifies HIF-dependent and independent mechanisms of regulation.
Ambrose LJ, Abd-Jamil AH, Gomes RS, Carter EE, Carr CA, Clarke K, Heather LC. Ambrose LJ, et al. Among authors: heather lc. J Cardiovasc Pharmacol Ther. 2014 Nov;19(6):574-85. doi: 10.1177/1074248414524480. Epub 2014 Mar 7. J Cardiovasc Pharmacol Ther. 2014. PMID: 24607765
Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism.
Tan SC, Gomes RS, Yeoh KK, Perbellini F, Malandraki-Miller S, Ambrose L, Heather LC, Faggian G, Schofield CJ, Davies KE, Clarke K, Carr CA. Tan SC, et al. Among authors: heather lc. Cell Transplant. 2016;25(1):35-53. doi: 10.3727/096368915X687697. Epub 2015 Mar 6. Cell Transplant. 2016. PMID: 25751158 Free PMC article.
Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation.
Mansor LS, Mehta K, Aksentijevic D, Carr CA, Lund T, Cole MA, Le Page L, Sousa Fialho Mda L, Shattock MJ, Aasum E, Clarke K, Tyler DJ, Heather LC. Mansor LS, et al. Among authors: heather lc. J Physiol. 2016 Jan 15;594(2):307-20. doi: 10.1113/JP271242. Epub 2015 Dec 20. J Physiol. 2016. PMID: 26574233 Free PMC article.
On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.
Cole MA, Abd Jamil AH, Heather LC, Murray AJ, Sutton ER, Slingo M, Sebag-Montefiore L, Tan SC, Aksentijević D, Gildea OS, Stuckey DJ, Yeoh KK, Carr CA, Evans RD, Aasum E, Schofield CJ, Ratcliffe PJ, Neubauer S, Robbins PA, Clarke K. Cole MA, et al. Among authors: heather lc. FASEB J. 2016 Aug;30(8):2684-97. doi: 10.1096/fj.201500094R. Epub 2016 Apr 21. FASEB J. 2016. PMID: 27103577 Free PMC article.
59 results