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Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression.
Delgado-Diaz DJ, Jesaveluk B, Hayward JA, Tyssen D, Alisoltani A, Potgieter M, Bell L, Ross E, Iranzadeh A, Allali I, Dabee S, Barnabas S, Gamieldien H, Blackburn JM, Mulder N, Smith SB, Edwards VL, Burgener AD, Bekker LG, Ravel J, Passmore JS, Masson L, Hearps AC, Tachedjian G. Delgado-Diaz DJ, et al. Among authors: hearps ac. Microbiome. 2022 Aug 31;10(1):141. doi: 10.1186/s40168-022-01337-5. Microbiome. 2022. PMID: 36045402 Free PMC article.
Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations.
Telwatte S, Hearps AC, Johnson A, Latham CF, Moore K, Agius P, Tachedjian M, Sonza S, Sluis-Cremer N, Harrigan PR, Tachedjian G. Telwatte S, et al. Among authors: hearps ac. Nucleic Acids Res. 2015 Mar 31;43(6):3256-71. doi: 10.1093/nar/gkv128. Epub 2015 Mar 12. Nucleic Acids Res. 2015. PMID: 25765644 Free PMC article.
Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition.
Hearps AC, Tyssen D, Srbinovski D, Bayigga L, Diaz DJD, Aldunate M, Cone RA, Gugasyan R, Anderson DJ, Tachedjian G. Hearps AC, et al. Mucosal Immunol. 2017 Nov;10(6):1480-1490. doi: 10.1038/mi.2017.27. Epub 2017 Apr 12. Mucosal Immunol. 2017. PMID: 28401934 Free article.
Distinct Immune Responses Elicited From Cervicovaginal Epithelial Cells by Lactic Acid and Short Chain Fatty Acids Associated With Optimal and Non-optimal Vaginal Microbiota.
Delgado-Diaz DJ, Tyssen D, Hayward JA, Gugasyan R, Hearps AC, Tachedjian G. Delgado-Diaz DJ, et al. Among authors: hearps ac. Front Cell Infect Microbiol. 2020 Jan 10;9:446. doi: 10.3389/fcimb.2019.00446. eCollection 2019. Front Cell Infect Microbiol. 2020. PMID: 31998660 Free PMC article.
66 results