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ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation.
bioRxiv [Preprint]. 2023 Mar 7:2023.03.07.531538. doi: 10.1101/2023.03.07.531538.
bioRxiv. 2023.
PMID: 36945424
Free PMC article.
Preprint.
S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity.
Puthenveetil R, Lun CM, Murphy RE, Healy LB, Vilmen G, Christenson ET, Freed EO, Banerjee A.
Puthenveetil R, et al. Among authors: healy lb.
J Biol Chem. 2021 Oct;297(4):101112. doi: 10.1016/j.jbc.2021.101112. Epub 2021 Aug 21.
J Biol Chem. 2021.
PMID: 34428449
Free PMC article.
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Orthogonal Enzyme-Substrate Design Strategy for Discovery of Human Protein Palmitoyltransferase Substrates.
Puthenveetil R, Auger SA, Gómez-Navarro N, Rana MS, Das R, Healy LB, Suazo KF, Shi ZD, Swenson RE, Distefano MD, Banerjee A.
Puthenveetil R, et al. Among authors: healy lb.
J Am Chem Soc. 2023 Oct 18;145(41):22287-22292. doi: 10.1021/jacs.3c04359. Epub 2023 Sep 29.
J Am Chem Soc. 2023.
PMID: 37774000
Free PMC article.
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ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.
Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, Puthenveetil R, Banerjee A, Luo HR, Kagan JC, Oh SF, Robinson CV, Lieberman J, Wu H.
Du G, et al. Among authors: healy lb.
Nature. 2024 Apr 10. doi: 10.1038/s41586-024-07373-5. Online ahead of print.
Nature. 2024.
PMID: 38599239
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Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens.
Healy LB, Du G, Wu H.
Healy LB, et al.
Trends Immunol. 2023 Aug;44(8):571-573. doi: 10.1016/j.it.2023.06.006. Epub 2023 Jul 4.
Trends Immunol. 2023.
PMID: 37414717
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