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DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining.
Head PE, Kapoor-Vazirani P, Nagaraju GP, Zhang H, Rath SK, Luong NC, Haji-Seyed-Javadi R, Sesay F, Wang SY, Duong DM, Daddacha W, Minten EV, Song B, Danelia D, Liu X, Li S, Ortlund EA, Seyfried NT, Smalley DM, Wang Y, Deng X, Dynan WS, El-Rayes B, Davis AJ, Yu DS. Head PE, et al. Nucleic Acids Res. 2023 Aug 25;51(15):7972-7987. doi: 10.1093/nar/gkad549. Nucleic Acids Res. 2023. PMID: 37395399 Free PMC article.
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Zhang H, Head PE, Daddacha W, Park SH, Li X, Pan Y, Madden MZ, Duong DM, Xie M, Yu B, Warren MD, Liu EA, Dhere VR, Li C, Pradilla I, Torres MA, Wang Y, Dynan WS, Doetsch PW, Deng X, Seyfried NT, Gius D, Yu DS. Zhang H, et al. Among authors: head pe. Cell Rep. 2016 Feb 16;14(6):1435-1447. doi: 10.1016/j.celrep.2016.01.018. Epub 2016 Feb 4. Cell Rep. 2016. PMID: 26854234 Free PMC article.
SIRT2 orchestrates the DNA damage response.
Zhang H, Head PE, Yu DS. Zhang H, et al. Among authors: head pe. Cell Cycle. 2016 Aug 17;15(16):2089-2090. doi: 10.1080/15384101.2016.1184517. Epub 2016 May 6. Cell Cycle. 2016. PMID: 27153288 Free PMC article. No abstract available.
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
Daddacha W, Koyen AE, Bastien AJ, Head PE, Dhere VR, Nabeta GN, Connolly EC, Werner E, Madden MZ, Daly MB, Minten EV, Whelan DR, Schlafstein AJ, Zhang H, Anand R, Doronio C, Withers AE, Shepard C, Sundaram RK, Deng X, Dynan WS, Wang Y, Bindra RS, Cejka P, Rothenberg E, Doetsch PW, Kim B, Yu DS. Daddacha W, et al. Among authors: head pe. Cell Rep. 2017 Aug 22;20(8):1921-1935. doi: 10.1016/j.celrep.2017.08.008. Cell Rep. 2017. PMID: 28834754 Free PMC article.
Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation.
Manoli I, Sysol JR, Head PE, Epping MW, Gavrilova O, Crocker MK, Sloan JL, Koutsoukos SA, Wang C, Ktena YP, Mendelson S, Pass AR, Zerfas PM, Hoffmann V, Vernon HJ, Fletcher LA, Reynolds JC, Tsokos MG, Stratakis CA, Voss SD, Chen KY, Brown RJ, Hamosh A, Berry GT, Chen XS, Yanovski JA, Venditti CP. Manoli I, et al. Among authors: head pe. JCI Insight. 2024 Feb 22;9(4):e174097. doi: 10.1172/jci.insight.174097. JCI Insight. 2024. PMID: 38271099 Free PMC article.
Anaplerosis in action.
Head PE, Venditti CP. Head PE, et al. Nat Metab. 2023 Jan;5(1):5-7. doi: 10.1038/s42255-022-00724-4. Nat Metab. 2023. PMID: 36717753 Free PMC article.
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