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Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.
Aoun M, Coelho A, Krämer A, Saxena A, Sabatier P, Beusch CM, Lönnblom E, Geng M, Do NN, Xu Z, Zhang J, He Y, Romero Castillo L, Abolhassani H, Xu B, Viljanen J, Rorbach J, Fernandez Lahore G, Gjertsson I, Kastbom A, Sjöwall C, Kihlberg J, Zubarev RA, Burkhardt H, Holmdahl R. Aoun M, et al. Among authors: he y. J Exp Med. 2023 Nov 6;220(11):e20230101. doi: 10.1084/jem.20230101. Epub 2023 Sep 11. J Exp Med. 2023. PMID: 37695523 Free PMC article.
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation.
Kissel T, Ge C, Hafkenscheid L, Kwekkeboom JC, Slot LM, Cavallari M, He Y, van Schie KA, Vergroesen RD, Kampstra ASB, Reijm S, Stoeken-Rijsbergen G, Koeleman C, Voortman LM, Heitman LH, Xu B, Pruijn GJM, Wuhrer M, Rispens T, Huizinga TWJ, Scherer HU, Reth M, Holmdahl R, Toes REM. Kissel T, et al. Among authors: he y. Sci Adv. 2022 Feb 11;8(6):eabm1759. doi: 10.1126/sciadv.abm1759. Epub 2022 Feb 9. Sci Adv. 2022. PMID: 35138894 Free PMC article.
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis.
He Y, Ge C, Moreno-Giró À, Xu B, Beusch CM, Sandor K, Su J, Cheng L, Lönnblom E, Lundqvist C, Slot LM, Tong D, Urbonaviciute V, Liang B, Li T, Lahore GF, Aoun M, Malmström V, Rispens T, Ernfors P, Svensson CI, Scherer HU, Toes REM, Gjertsson I, Ekwall O, Zubarev RA, Holmdahl R. He Y, et al. Nat Commun. 2023 Feb 8;14(1):691. doi: 10.1038/s41467-023-36257-x. Nat Commun. 2023. PMID: 36754962 Free PMC article.
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.
Aoun M, Coelho A, Krämer A, Saxena A, Sabatier P, Beusch CM, Lönnblom E, Geng M, Do NN, Xu Z, Zhang J, He Y, Castillo LR, Abolhassani H, Xu B, Viljanen J, Rorbach J, Lahore GF, Gjertsson I, Kastbom A, Sjöwall C, Kihlberg J, Zubarev RA, Burkhardt H, Holmdahl R. Aoun M, et al. Among authors: he y. J Exp Med. 2023 Nov 6;220(11):e2023010109212023c. doi: 10.1084/jem.2023010109212023c. Epub 2023 Oct 3. J Exp Med. 2023. PMID: 37788218 Free PMC article. No abstract available.
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