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The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.
He X, Zhang X, Wu B, Deng J, Zhang Y, Zhu A, Yuan Y, Lin Y, Chen A, Feng J, Wang X, Wu S, Liu Y, Liu J, Wang Y, Li R, Liang C, Yuan Q, Liang Y, Fang Q, Xi Z, Li W, Liang L, Zhang Z, Tang H, Peng Y, Ke C, Ma X, Cai W, Pan T, Liu B, Deng K, Chen J, Zhao J, Wei X, Chen R, Zhang Y, Zhang H. He X, et al. Nat Immunol. 2024 Apr;25(4):622-632. doi: 10.1038/s41590-024-01776-2. Epub 2024 Mar 7. Nat Immunol. 2024. PMID: 38454157
Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses.
Ma X, Zou F, Yu F, Li R, Yuan Y, Zhang Y, Zhang X, Deng J, Chen T, Song Z, Qiao Y, Zhan Y, Liu J, Zhang J, Zhang X, Peng Z, Li Y, Lin Y, Liang L, Wang G, Chen Y, Chen Q, Pan T, He X, Zhang H. Ma X, et al. Among authors: he x. Immunity. 2020 Dec 15;53(6):1315-1330.e9. doi: 10.1016/j.immuni.2020.11.015. Epub 2020 Nov 25. Immunity. 2020. PMID: 33275896 Free PMC article.
Differential efficiencies to neutralize the novel mutants B.1.1.7 and 501Y.V2 by collected sera from convalescent COVID-19 patients and RBD nanoparticle-vaccinated rhesus macaques.
Li R, Ma X, Deng J, Chen Q, Liu W, Peng Z, Qiao Y, Lin Y, He X, Zhang H. Li R, et al. Among authors: he x. Cell Mol Immunol. 2021 Apr;18(4):1058-1060. doi: 10.1038/s41423-021-00641-8. Epub 2021 Feb 12. Cell Mol Immunol. 2021. PMID: 33580167 Free PMC article. No abstract available.
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