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Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.
He W, Henne A, Lauterbach M, Geißmar E, Nikolka F, Kho C, Heinz A, Dostert C, Grusdat M, Cordes T, Härm J, Goldmann O, Ewen A, Verschueren C, Blay-Cadanet J, Geffers R, Garritsen H, Kneiling M, Holm CK, Metallo CM, Medina E, Abdullah Z, Latz E, Brenner D, Hiller K. He W, et al. Nat Metab. 2022 May;4(5):524-533. doi: 10.1038/s42255-022-00565-1. Epub 2022 Jun 2. Nat Metab. 2022. PMID: 35655024 Free PMC article.
Itaconate controls its own synthesis via feedback-inhibition of reverse TCA cycle activity at IDH2.
Heinz A, Nonnenmacher Y, Henne A, Khalil MA, Bejkollari K, Dostert C, Hosseini S, Goldmann O, He W, Palorini R, Verschueren C, Korte M, Chiaradonna F, Medina E, Brenner D, Hiller K. Heinz A, et al. Among authors: he w. Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166530. doi: 10.1016/j.bbadis.2022.166530. Epub 2022 Aug 28. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 36038039 Free article.
Complexity of macrophage metabolism in infection.
He W, Heinz A, Jahn D, Hiller K. He W, et al. Curr Opin Biotechnol. 2021 Apr;68:231-239. doi: 10.1016/j.copbio.2021.01.020. Epub 2021 Feb 18. Curr Opin Biotechnol. 2021. PMID: 33610128 Review.
BCAT1 redox function maintains mitotic fidelity.
Francois L, Boskovic P, Knerr J, He W, Sigismondo G, Schwan C, More TH, Schlotter M, Conway ME, Krijgsveld J, Hiller K, Grosse R, Lichter P, Radlwimmer B. Francois L, et al. Among authors: he w. Cell Rep. 2022 Oct 18;41(3):111524. doi: 10.1016/j.celrep.2022.111524. Cell Rep. 2022. PMID: 36260995 Free article.
Ultrastructural insights into cellular organization, energy storage and ribosomal dynamics of an ammonia-oxidizing archaeon from oligotrophic oceans.
Zhou Y, Yan A, Yang J, He W, Guo S, Li Y, Wu J, Dai Y, Pan X, Cui D, Pereira O, Teng W, Bi R, Chen S, Fan L, Wang P, Liao Y, Qin W, Sui SF, Zhu Y, Zhang C, Liu Z. Zhou Y, et al. Among authors: he w. Front Microbiol. 2024 Apr 26;15:1367658. doi: 10.3389/fmicb.2024.1367658. eCollection 2024. Front Microbiol. 2024. PMID: 38737410 Free PMC article.
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