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Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Root AR, Cao W, Li B, LaPan P, Meade C, Sanford J, Jin M, O'Sullivan C, Cummins E, Lambert M, Sheehan AD, Ma W, Gatto S, Kerns K, Lam K, D'Antona AM, Zhu L, Brady WA, Benard S, King A, He T, Racie L, Arai M, Barrett D, Stochaj W, LaVallie ER, Apgar JR, Svenson K, Mosyak L, Yang Y, Chichili GR, Liu L, Li H, Burke S, Johnson S, Alderson R, Finlay WJJ, Lin L, Olland S, Somers W, Bonvini E, Gerber HP, May C, Moore PA, Tchistiakova L, Bloom L. Root AR, et al. Among authors: he t. Antibodies (Basel). 2016 Mar 4;5(1):6. doi: 10.3390/antib5010006. Antibodies (Basel). 2016. PMID: 31557987 Free PMC article.
Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation.
Fung E, Kang L, Sapashnik D, Benard S, Sievers A, Liu Y, Yan G, Zhou J, Rodriguez L, Ma W, Stochaj WR, LaVallie E, Wroblewska L, Kelleher K, Tam A, Bezy O, Breen D, Chabot JR, He T, Lin L, Wu Z, Mosyak L. Fung E, et al. Among authors: he t. Sci Rep. 2021 Apr 26;11(1):8921. doi: 10.1038/s41598-021-87959-5. Sci Rep. 2021. PMID: 33903632 Free PMC article.
Mechanistic understanding of the cysteine capping modifications of antibodies enables selective chemical engineering in live mammalian cells.
Zhong X, He T, Prashad AS, Wang W, Cohen J, Ferguson D, Tam AS, Sousa E, Lin L, Tchistiakova L, Gatto S, D'Antona A, Luan YT, Ma W, Zollner R, Zhou J, Arve B, Somers W, Kriz R. Zhong X, et al. Among authors: he t. J Biotechnol. 2017 Apr 20;248:48-58. doi: 10.1016/j.jbiotec.2017.03.006. Epub 2017 Mar 11. J Biotechnol. 2017. PMID: 28300660
Pyroglutamate and O-linked glycan determine functional production of anti-IL17A and anti-IL22 peptide-antibody bispecific genetic fusions.
Zhong X, Kieras E, Sousa E, D'Antona A, Baber JC, He T, Desharnais J, Wood L, Luxenberg D, Stahl M, Kriz R, Lin L, Somers W, Fitz LJ, Wright JF. Zhong X, et al. Among authors: he t. J Biol Chem. 2013 Jan 11;288(2):1409-19. doi: 10.1074/jbc.M112.417717. Epub 2012 Nov 26. J Biol Chem. 2013. PMID: 23184956 Free PMC article.
Drug target identification and quantitative proteomics.
He T, Jin Kim Y, Heidbrink JL, Moore PA, Ruben SM. He T, et al. Expert Opin Drug Discov. 2006 Oct;1(5):477-89. doi: 10.1517/17460441.1.5.477. Expert Opin Drug Discov. 2006. PMID: 23495947
Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing.
Weng Y, Ishino T, Sievers A, Talukdar S, Chabot JR, Tam A, Duan W, Kerns K, Sousa E, He T, Logan A, Lee D, Li D, Zhou Y, Bernardo B, Joyce A, Kavosi M, O'Hara DM, Clark T, Guo J, Giragossian C, Stahl M, Calle RA, Kriz R, Somers W, Lin L. Weng Y, et al. Among authors: he t. Sci Rep. 2018 Mar 9;8(1):4241. doi: 10.1038/s41598-018-22456-w. Sci Rep. 2018. PMID: 29523796 Free PMC article.
5,021 results