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Page 1
Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP. Huang SM, et al. Among authors: he qt. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2216329120. doi: 10.1073/pnas.2216329120. Epub 2023 Jul 21. Proc Natl Acad Sci U S A. 2023. PMID: 37478163 Free PMC article.
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.
Yang F, Xiao P, Qu CX, Liu Q, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X, Sun JP, Wang J. Yang F, et al. Among authors: he qt, he df. Nat Chem Biol. 2018 Sep;14(9):876-886. doi: 10.1038/s41589-018-0115-3. Epub 2018 Aug 17. Nat Chem Biol. 2018. PMID: 30120361
Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade.
Qu C, Park JY, Yun MW, He QT, Yang F, Kim K, Ham D, Li RR, Iverson TM, Gurevich VV, Sun JP, Chung KY. Qu C, et al. Among authors: he qt. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2026491118. doi: 10.1073/pnas.2026491118. Proc Natl Acad Sci U S A. 2021. PMID: 34507982 Free PMC article.
Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4.
Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X. Xiao P, et al. Among authors: he qt. Nature. 2022 Apr;604(7907):771-778. doi: 10.1038/s41586-022-04590-8. Epub 2022 Apr 13. Nature. 2022. PMID: 35418677
Structures of the ADGRG2-Gs complex in apo and ligand-bound forms.
Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X. Lin H, et al. Among authors: he qt. Nat Chem Biol. 2022 Nov;18(11):1196-1203. doi: 10.1038/s41589-022-01084-6. Epub 2022 Aug 18. Nat Chem Biol. 2022. PMID: 35982227
DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe.
Liu Q, He QT, Lyu X, Yang F, Zhu ZL, Xiao P, Yang Z, Zhang F, Yang ZY, Wang XY, Sun P, Wang QW, Qu CX, Gong Z, Lin JY, Xu Z, Song SL, Huang SM, Guo SC, Han MJ, Zhu KK, Chen X, Kahsai AW, Xiao KH, Kong W, Li FH, Ruan K, Li ZJ, Yu X, Niu XG, Jin CW, Wang J, Sun JP. Liu Q, et al. Among authors: he qt. Nat Commun. 2020 Sep 25;11(1):4857. doi: 10.1038/s41467-020-18433-5. Nat Commun. 2020. PMID: 32978402 Free PMC article.
Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP. Mao C, et al. Among authors: he qt. Science. 2023 Apr 7;380(6640):eadd6220. doi: 10.1126/science.add6220. Epub 2023 Apr 7. Science. 2023. PMID: 36862765
Crystal structure and catalytic activity of the PPM1K N94K mutant.
Dolatabad MR, Guo LL, Xiao P, Zhu Z, He QT, Yang DX, Qu CX, Guo SC, Fu XL, Li RR, Ge L, Hu KJ, Liu HD, Shen YM, Yu X, Sun JP, Zhang PJ. Dolatabad MR, et al. Among authors: he qt. J Neurochem. 2019 Feb;148(4):550-560. doi: 10.1111/jnc.14631. Epub 2019 Jan 3. J Neurochem. 2019. PMID: 30451284 Free article.
30 results