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PVRIG is expressed on stem-like T cells in dendritic cell-rich niches in tumors and its blockade may induce immune infiltration in non-inflamed tumors.
Alteber Z, Cojocaru G, Granit RZ, Barbiro I, Wool A, Frenkel M, Novik A, Shuchami A, Liang Y, Carmi VD, Sabath N, Foreman R, Petrenko N, He J, Kliger Y, Levy-Barda A, Eitan R, Raban O, Sadot E, Sulimani O, Nathan AA, Adewoye H, Ferre P, Levine Z, Ophir E. Alteber Z, et al. Among authors: he j. Cancer Immunol Res. 2024 May 16. doi: 10.1158/2326-6066.CIR-23-0752. Online ahead of print. Cancer Immunol Res. 2024. PMID: 38752503
Reactive Oxygen Species-Responsive Delivery of a Notch Inhibitor to Alleviate Nonalcoholic Steatohepatitis by Inhibiting Hepatic de Novo Lipogenesis and Inflammation.
Chen J, Zhang J, Xia Y, Li J, Jia Q, Zhang Z, Jing X, Xu Y, Zou L, Wang L, Song H, Li J, Liu Q, Xiong Y, Tang Q, Chen W, Yang N, Xu H, Li Y, He J. Chen J, et al. Among authors: he j. Mol Pharm. 2024 May 15. doi: 10.1021/acs.molpharmaceut.4c00070. Online ahead of print. Mol Pharm. 2024. PMID: 38751169
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