Hazuda D - Search Results

1

Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.

Gardelli C, Nizi E, Muraglia E, Crescenzi B, Ferrara M, Orvieto F, Pace P, Pescatore G, Poma M, Ferreira Mdel R, Scarpelli R, Homnick CF, Ikemoto N, Alfieri A, Verdirame M, Bonelli F, Paz OG, Taliani M, Monteagudo E, Pesci S, Laufer R, Felock P, Stillmock KA, Hazuda D, Rowley M, Summa V. Gardelli C, et al. Among authors: hazuda d. J Med Chem. 2007 Oct 4;50(20):4953-75. doi: 10.1021/jm0704705. Epub 2007 Sep 8. J Med Chem. 2007. PMID: 17824681

2

The role of manganese in promoting multimerization and assembly of human immunodeficiency virus type 1 integrase as a catalytically active complex on immobilized long terminal repeat substrates.

Wolfe AL, Felock PJ, Hastings JC, Blau CU, Hazuda DJ. Wolfe AL, et al. Among authors: hazuda dj. J Virol. 1996 Mar;70(3):1424-32. doi: 10.1128/JVI.70.3.1424-1432.1996. J Virol. 1996. PMID: 8627659 Free PMC article.

A microtiter assay for the strand transfer activity of human immunodeficiency virus type 1 integrase which uses an immobilized oligonucleotide as the donor substrate was previously published (D. J. Hazuda, J. C. Hastings, A. L. Wolfe, and E. A. Emini, Nucleic Acids …

A microtiter assay for the strand transfer activity of human immunodeficiency virus type 1 integrase which uses an immobilized oligonucleoti …

3

Equivalent inhibition of half-site and full-site retroviral strand transfer reactions by structurally diverse compounds.

Hazuda D, Felock P, Hastings J, Pramanik B, Wolfe A, Goodarzi G, Vora A, Brackmann K, Grandgenett D. Hazuda D, et al. J Virol. 1997 Jan;71(1):807-11. doi: 10.1128/JVI.71.1.807-811.1997. J Virol. 1997. PMID: 8985421 Free PMC article.

4

Differential divalent cation requirements uncouple the assembly and catalytic reactions of human immunodeficiency virus type 1 integrase.

Hazuda DJ, Felock PJ, Hastings JC, Pramanik B, Wolfe AL. Hazuda DJ, et al. J Virol. 1997 Sep;71(9):7005-11. doi: 10.1128/JVI.71.9.7005-7011.1997. J Virol. 1997. PMID: 9261430 Free PMC article.

5

Discovery and analysis of inhibitors of the human immunodeficiency integrase.

Hazuda D, Felock PJ, Hastings JC, Pramanik B, Wolfe AL. Hazuda D, et al. Drug Des Discov. 1997 May;15(1):17-24. Drug Des Discov. 1997. PMID: 9332828

6

Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites.

Hazuda D, Blau CU, Felock P, Hastings J, Pramanik B, Wolfe A, Bushman F, Farnet C, Goetz M, Williams M, Silverman K, Lingham R, Singh S. Hazuda D, et al. Antivir Chem Chemother. 1999 Mar;10(2):63-70. doi: 10.1177/095632029901000202. Antivir Chem Chemother. 1999. PMID: 10335400 Free article.

7

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.

Hazuda DJ, Felock P, Witmer M, Wolfe A, Stillmock K, Grobler JA, Espeseth A, Gabryelski L, Schleif W, Blau C, Miller MD. Hazuda DJ, et al. Science. 2000 Jan 28;287(5453):646-50. doi: 10.1126/science.287.5453.646. Science. 2000. PMID: 10649997

8

X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform.

Chen Z, Yan Y, Munshi S, Li Y, Zugay-Murphy J, Xu B, Witmer M, Felock P, Wolfe A, Sardana V, Emini EA, Hazuda D, Kuo LC. Chen Z, et al. Among authors: hazuda d. J Mol Biol. 2000 Feb 18;296(2):521-33. doi: 10.1006/jmbi.1999.3451. J Mol Biol. 2000. PMID: 10669606

9

Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity.

Singh SB, Felock P, Hazuda DJ. Singh SB, et al. Among authors: hazuda dj. Bioorg Med Chem Lett. 2000 Feb 7;10(3):235-8. doi: 10.1016/s0960-894x(99)00666-6. Bioorg Med Chem Lett. 2000. PMID: 10698443

10

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.

Espeseth AS, Felock P, Wolfe A, Witmer M, Grobler J, Anthony N, Egbertson M, Melamed JY, Young S, Hamill T, Cole JL, Hazuda DJ. Espeseth AS, et al. Among authors: hazuda dj. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11244-9. doi: 10.1073/pnas.200139397. Proc Natl Acad Sci U S A. 2000. PMID: 11016953 Free PMC article.

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