Haythorne E - Search Results

1

Editorial: Ion channels and transporters in diabetes and metabolic diseases.

Puljung M, Haythorne E, Rohm M, Vedovato N. Puljung M, et al. Among authors: haythorne e. Front Pharmacol. 2022 Aug 22;13:975812. doi: 10.3389/fphar.2022.975812. eCollection 2022. Front Pharmacol. 2022. PMID: 36071853 Free PMC article. No abstract available.

2

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.

Haythorne E, Rohm M, van de Bunt M, Brereton MF, Tarasov AI, Blacker TS, Sachse G, Silva Dos Santos M, Terron Exposito R, Davis S, Baba O, Fischer R, Duchen MR, Rorsman P, MacRae JI, Ashcroft FM. Haythorne E, et al. Nat Commun. 2019 Jun 6;10(1):2474. doi: 10.1038/s41467-019-10189-x. Nat Commun. 2019. PMID: 31171772 Free PMC article.

3

Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.

Haythorne E, Lloyd M, Walsby-Tickle J, Tarasov AI, Sandbrink J, Portillo I, Exposito RT, Sachse G, Cyranka M, Rohm M, Rorsman P, McCullagh J, Ashcroft FM. Haythorne E, et al. Nat Commun. 2022 Nov 14;13(1):6754. doi: 10.1038/s41467-022-34095-x. Nat Commun. 2022. PMID: 36376280 Free PMC article.

4

Binding of sulphonylureas to plasma proteins - A KATP channel perspective.

Proks P, Kramer H, Haythorne E, Ashcroft FM. Proks P, et al. Among authors: haythorne e. PLoS One. 2018 May 17;13(5):e0197634. doi: 10.1371/journal.pone.0197634. eCollection 2018. PLoS One. 2018. PMID: 29772022 Free PMC article.

5

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.

Knudsen JG, Hamilton A, Ramracheya R, Tarasov AI, Brereton M, Haythorne E, Chibalina MV, Spégel P, Mulder H, Zhang Q, Ashcroft FM, Adam J, Rorsman P. Knudsen JG, et al. Among authors: haythorne e. Cell Metab. 2019 Feb 5;29(2):430-442.e4. doi: 10.1016/j.cmet.2018.10.003. Epub 2018 Nov 8. Cell Metab. 2019. PMID: 30415925 Free PMC article.

6

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion.

Sachse G, Haythorne E, Hill T, Proks P, Joynson R, Terrón-Expósito R, Bentley L, Tucker SJ, Cox RD, Ashcroft FM. Sachse G, et al. Among authors: haythorne e. Diabetes. 2021 May;70(5):1145-1156. doi: 10.2337/db20-0691. Epub 2021 Feb 10. Diabetes. 2021. PMID: 33568422

7

Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice.

Sachse G, Haythorne E, Proks P, Stewart M, Cater H, Ellard S, Davies B, Ashcroft FM. Sachse G, et al. Among authors: haythorne e. Wellcome Open Res. 2021 Mar 15;5:15. doi: 10.12688/wellcomeopenres.15529.2. eCollection 2020. Wellcome Open Res. 2021. PMID: 34368464 Free PMC article.

8

Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.

Martinez-Sanchez A, Pullen TJ, Chabosseau P, Zhang Q, Haythorne E, Cane MC, Nguyen-Tu MS, Sayers SR, Rutter GA. Martinez-Sanchez A, et al. Among authors: haythorne e. Diabetes. 2016 May;65(5):1268-82. doi: 10.2337/db15-1240. Epub 2016 Feb 9. Diabetes. 2016. PMID: 26861785 Free PMC article.

9

Local and regional control of calcium dynamics in the pancreatic islet.

Rutter GA, Hodson DJ, Chabosseau P, Haythorne E, Pullen TJ, Leclerc I. Rutter GA, et al. Among authors: haythorne e. Diabetes Obes Metab. 2017 Sep;19 Suppl 1:30-41. doi: 10.1111/dom.12990. Diabetes Obes Metab. 2017. PMID: 28466490 Free article. Review.

10

The pore-forming subunit MCU of the mitochondrial Ca²⁺ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.

Georgiadou E, Haythorne E, Dickerson MT, Lopez-Noriega L, Pullen TJ, da Silva Xavier G, Davis SPX, Martinez-Sanchez A, Semplici F, Rizzuto R, McGinty JA, French PM, Cane MC, Jacobson DA, Leclerc I, Rutter GA. Georgiadou E, et al. Among authors: haythorne e. Diabetologia. 2020 Jul;63(7):1368-1381. doi: 10.1007/s00125-020-05148-x. Epub 2020 Apr 29. Diabetologia. 2020. PMID: 32350566 Free PMC article.

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